Explore RNASEH2A gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a component of the heterotrimeric type II ribonuclease H enzyme (RNAseH2). RNAseH2 is the major source of ribonuclease H activity in mammalian cells and endonucleolytically cleaves ribonucleotides. It is predicted to remove Okazaki fragment RNA primers during lagging strand DNA synthesis and to excise single ribonucleotides from DNA-DNA duplexes. Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid.[provided by RefSeq, Aug 2009]
| Target ID |
GM-TA020
|
| Target Name |
RNASEH2A
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10535
|
| Gene ID |
100064237 (Equus caballus), 100856442 (Canis lupus familiaris), 101086121 (Felis catus), 10535 (Homo sapiens)
364974 (Rattus norvegicus), 512830 (Bos taurus), 69724 (Mus musculus), 716701 (Macaca mulatta)
|
| Target Alternative Names |
RNASEH2A,Rnaseh2a,AGS4,JUNB,RNHL,RNHIA,RNASEHI,2400006P09Rik
|
| Uniprot Accession |
O75792,Q5U209,Q2TBT5,Q9CWY8
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000007013, ENSCAFG00845015846, ENSG00000104889, ENSBTAG00000009661, ENSMUSG00000052926, ENSMMUG00000045010
|
| Target Classification |
|
Pre-made viral vector of RNASEH2A cDNA Clones/ORF Plasmid
RNASEH2A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10535 | Pre-made Human RNASEH2A/AGS4/JUNB siRNA oligo Duplex | 10535 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo364974 | Pre-made Rat Rnaseh2a siRNA oligo Duplex | 364974 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo69724 | Pre-made Mouse Rnaseh2a/RNHL/RNHIA siRNA oligo Duplex | 69724 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716701 | Pre-made Cynomolgus/Rhesus macaque RNASEH2A siRNA oligo Duplex | 716701 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086121 | Pre-made Cat/Feline RNASEH2A siRNA oligo Duplex | 101086121 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100856442 | Pre-made Dog/Canine RNASEH2A siRNA oligo Duplex | 100856442 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512830 | Pre-made Bovines/Cattle RNASEH2A siRNA oligo Duplex | 512830 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064237 | Pre-made Equine/Horse RNASEH2A siRNA oligo Duplex | 100064237 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
RNASEH2A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-TA020-Ab | Human | Anti-Human RNASEH2A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-TA020-Ab | Rat | Anti-Rat RNASEH2A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-TA020-Ab | Mouse | Anti-Mouse RNASEH2A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-TA020-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque RNASEH2A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-TA020-Ab | Cat/Feline | Anti-Cat/Feline RNASEH2A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-TA020-Ab | Dog/Canine | Anti-Dog/Canine RNASEH2A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-TA020-Ab | Bovines/Cattle | Anti-Bovines/Cattle RNASEH2A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-TA020-Ab | Equine/Horse | Anti-Equine/Horse RNASEH2A monoclonal antibody | mab | Therapeutics Target antibody | Detail |
RNASEH2A recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-TA020-Ag | Human | Human RNASEH2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-TA020-Ag | Rat | Rat RNASEH2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-TA020-Ag | Mouse | Mouse RNASEH2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-TA020-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque RNASEH2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-TA020-Ag | Cat/Feline | Cat/Feline RNASEH2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-TA020-Ag | Dog/Canine | Dog/Canine RNASEH2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-TA020-Ag | Bovines/Cattle | Bovines/Cattle RNASEH2A recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-TA020-Ag | Equine/Horse | Equine/Horse RNASEH2A recombinant protein | Mammalian cell | Detail |
