Explore FGF18 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T99732
|
| Target Name |
FGF18
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
8817
|
| Gene ID |
100629648 (Equus caballus), 101098518 (Felis catus), 14172 (Mus musculus), 29369 (Rattus norvegicus) 533929 (Bos taurus), 611641 (Canis lupus familiaris), 702072 (Macaca mulatta), 8817 (Homo sapiens)
|
| Target Alternative Names |
D130055P09Rik,FGF-18,FGF18,FGF6A,Fgf18,Fgf6a,Fibroblast growth factor 18,ZFGF5,zFGF5
|
| Uniprot Accession |
O89101,O88182,Q0VCA0,O76093
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
Breast Cancer
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Chemical carcinogenesis - receptor activation, Melanoma, Breast cancer, Gastric cancer
|
| Gene Ensembl |
ENSECAG00000030850, ENSMUSG00000057967, ENSBTAG00000000128, ENSCAFG00845001658, ENSMMUG00000019401, ENSG00000156427
|
Pre-made viral vector of FGF18 cDNA Clones/ORF Plasmid
FGF18 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8817 | Pre-made Human FGF18/ZFGF5/FGF-18 siRNA oligo Duplex | 8817 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29369 | Pre-made Rat Fgf18 siRNA oligo Duplex | 29369 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14172 | Pre-made Mouse Fgf18/Fgf6a/FGF-18 siRNA oligo Duplex | 14172 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo702072 | Pre-made Cynomolgus/Rhesus macaque FGF18 siRNA oligo Duplex | 702072 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098518 | Pre-made Cat/Feline FGF18 siRNA oligo Duplex | 101098518 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo611641 | Pre-made Dog/Canine FGF18 siRNA oligo Duplex | 611641 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo533929 | Pre-made Bovines/Cattle FGF18/FGF6A siRNA oligo Duplex | 533929 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100629648 | Pre-made Equine/Horse FGF18 siRNA oligo Duplex | 100629648 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FGF18 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T99732-Ab | Human | Anti-Human FGF18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T99732-Ab | Rat | Anti-Rat FGF18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T99732-Ab | Mouse | Anti-Mouse FGF18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T99732-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FGF18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T99732-Ab | Cat/Feline | Anti-Cat/Feline FGF18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T99732-Ab | Dog/Canine | Anti-Dog/Canine FGF18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T99732-Ab | Bovines/Cattle | Anti-Bovines/Cattle FGF18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T99732-Ab | Equine/Horse | Anti-Equine/Horse FGF18 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
FGF18 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T99732-Ag | Human | Human FGF18 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T99732-Ag | Rat | Rat FGF18 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T99732-Ag | Mouse | Mouse FGF18 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T99732-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FGF18 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T99732-Ag | Cat/Feline | Cat/Feline FGF18 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T99732-Ag | Dog/Canine | Dog/Canine FGF18 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T99732-Ag | Bovines/Cattle | Bovines/Cattle FGF18 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T99732-Ag | Equine/Horse | Equine/Horse FGF18 recombinant protein | Mammalian cell | Detail |