Explore PDK3/PDHK3 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
| Target ID |
GM-T99029
|
| Target Name |
PDK3/PDHK3
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5165
|
| Gene ID |
100060791 (Equus caballus), 101095314 (Felis catus), 119868412 (Canis lupus familiaris), 236900 (Mus musculus) 296849 (Rattus norvegicus), 510841 (Bos taurus), 5165 (Homo sapiens), 699394 (Macaca mulatta)
|
| Target Alternative Names |
2610001M10Rik,CMTX6,GS1-358P8.4,PDHK3,PDK3,Pdk3,Pyruvate dehydrogenase kinase isoform 3,[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3,mitochondrial
|
| Uniprot Accession |
Q922H2,Q15120
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000010080, ENSCAFG00845030590, ENSMUSG00000035232, ENSBTAG00000017832, ENSG00000067992, ENSMMUG00000012819
|
Pre-made viral vector of PDK3/PDHK3 cDNA Clones/ORF Plasmid
PDK3/PDHK3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5165 | Pre-made Human PDK3/CMTX6/GS1-358P8.4 siRNA oligo Duplex | 5165 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo296849 | Pre-made Rat Pdk3 siRNA oligo Duplex | 296849 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo236900 | Pre-made Mouse Pdk3/2610001M10Rik siRNA oligo Duplex | 236900 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699394 | Pre-made Cynomolgus/Rhesus macaque PDK3 siRNA oligo Duplex | 699394 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095314 | Pre-made Cat/Feline PDK3 siRNA oligo Duplex | 101095314 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo119868412 | Pre-made Dog/Canine PDK3 siRNA oligo Duplex | 119868412 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo510841 | Pre-made Bovines/Cattle PDK3 siRNA oligo Duplex | 510841 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060791 | Pre-made Equine/Horse PDK3 siRNA oligo Duplex | 100060791 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PDK3/PDHK3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T99029-Ab | Human | Anti-Human PDK3/PDHK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T99029-Ab | Rat | Anti-Rat PDK3/PDHK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T99029-Ab | Mouse | Anti-Mouse PDK3/PDHK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T99029-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PDK3/PDHK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T99029-Ab | Cat/Feline | Anti-Cat/Feline PDK3/PDHK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T99029-Ab | Dog/Canine | Anti-Dog/Canine PDK3/PDHK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T99029-Ab | Bovines/Cattle | Anti-Bovines/Cattle PDK3/PDHK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T99029-Ab | Equine/Horse | Anti-Equine/Horse PDK3/PDHK3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PDK3/PDHK3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T99029-Ag | Human | Human PDK3/PDHK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T99029-Ag | Rat | Rat PDK3/PDHK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T99029-Ag | Mouse | Mouse PDK3/PDHK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T99029-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PDK3/PDHK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T99029-Ag | Cat/Feline | Cat/Feline PDK3/PDHK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T99029-Ag | Dog/Canine | Dog/Canine PDK3/PDHK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T99029-Ag | Bovines/Cattle | Bovines/Cattle PDK3/PDHK3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T99029-Ag | Equine/Horse | Equine/Horse PDK3/PDHK3 recombinant protein | Mammalian cell | Detail |