Explore Thyroid Hormone Receptor beta/THRB gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T98933
|
| Target Name |
Thyroid Hormone Receptor beta/THRB
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7068
|
| Gene ID |
100051615 (Equus caballus), 100429549 (Macaca mulatta), 101084821 (Felis catus), 21834 (Mus musculus) 24831 (Rattus norvegicus), 403599 (Canis lupus familiaris), 7068 (Homo sapiens), 788329 (Bos taurus)
|
| Target Alternative Names |
C-ERBA-2,C-ERBA-BETA,C-erba-beta,ERBA2,GRTH,NR1A2,Nr1a2,Nuclear receptor subfamily 1 group A member 2,PRTH,RATT3REC,T3R[b],T3Rbeta,T3rec,THR,THR1,THRB,THRB1,THRB2,THRbeta,THRbeta1,TRb,TRbeta,TRbeta1,Thrb,Thrb1,Thrb2,Thrbeta2,Thyroid Hormone Receptor beta,Thyroid hormone receptor beta,c-erbA-2,c-erbA-beta,c-erbAbeta
|
| Uniprot Accession |
P37242,P18113,P10828
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Neuroactive ligand-receptor interaction, Thyroid hormone signaling pathway
|
| Gene Ensembl |
ENSECAG00000019007, ENSMMUG00000000067, ENSMUSG00000021779, ENSCAFG00845019516, ENSG00000151090, ENSBTAG00000017802
|
| Target Classification |
Nuclear Receptors, Tumor-associated antigen (TAA)
|
Pre-made viral vector of Thyroid Hormone Receptor beta/THRB cDNA Clones/ORF Plasmid
Thyroid Hormone Receptor beta/THRB siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7068 | Pre-made Human THRB/TRb/GRTH siRNA oligo Duplex | 7068 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24831 | Pre-made Rat Thrb/ERBA2/Nr1a2 siRNA oligo Duplex | 24831 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo21834 | Pre-made Mouse Thrb/Nr1a2/Thrb1 siRNA oligo Duplex | 21834 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100429549 | Pre-made Cynomolgus/Rhesus macaque THRB siRNA oligo Duplex | 100429549 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084821 | Pre-made Cat/Feline THRB siRNA oligo Duplex | 101084821 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403599 | Pre-made Dog/Canine THRB/THR siRNA oligo Duplex | 403599 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo788329 | Pre-made Bovines/Cattle THRB/TRbeta1 siRNA oligo Duplex | 788329 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051615 | Pre-made Equine/Horse THRB siRNA oligo Duplex | 100051615 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Thyroid Hormone Receptor beta/THRB antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T98933-Ab | Human | Anti-Human Thyroid Hormone Receptor beta/THRB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T98933-Ab | Rat | Anti-Rat Thyroid Hormone Receptor beta/THRB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T98933-Ab | Mouse | Anti-Mouse Thyroid Hormone Receptor beta/THRB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T98933-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Thyroid Hormone Receptor beta/THRB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T98933-Ab | Cat/Feline | Anti-Cat/Feline Thyroid Hormone Receptor beta/THRB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T98933-Ab | Dog/Canine | Anti-Dog/Canine Thyroid Hormone Receptor beta/THRB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T98933-Ab | Bovines/Cattle | Anti-Bovines/Cattle Thyroid Hormone Receptor beta/THRB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T98933-Ab | Equine/Horse | Anti-Equine/Horse Thyroid Hormone Receptor beta/THRB monoclonal antibody | mab | Therapeutics Target antibody | Detail |
Thyroid Hormone Receptor beta/THRB recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T98933-Ag | Human | Human Thyroid Hormone Receptor beta/THRB recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T98933-Ag | Rat | Rat Thyroid Hormone Receptor beta/THRB recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T98933-Ag | Mouse | Mouse Thyroid Hormone Receptor beta/THRB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T98933-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Thyroid Hormone Receptor beta/THRB recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T98933-Ag | Cat/Feline | Cat/Feline Thyroid Hormone Receptor beta/THRB recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T98933-Ag | Dog/Canine | Dog/Canine Thyroid Hormone Receptor beta/THRB recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T98933-Ag | Bovines/Cattle | Bovines/Cattle Thyroid Hormone Receptor beta/THRB recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T98933-Ag | Equine/Horse | Equine/Horse Thyroid Hormone Receptor beta/THRB recombinant protein | Mammalian cell | Detail |