Explore Caspase 1/CASP1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Introcelluar Protein.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
| Target ID |
GM-T98269
|
| Target Name |
Caspase 1/CASP1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
834
|
| Gene ID |
25166 (Rattus norvegicus), 514214 (Bos taurus), 834 (Homo sapiens)
|
| Target Alternative Names |
CASP-1,CASP1,Casp1,Caspase 1,Caspase-1,ICE,IL-1 beta-converting enzyme),IL1BC,Ice,Il1bc,Interleukin-1 beta convertase (IL-1BC),Interleukin-1 beta-converting enzyme (ICE,P45,p45
|
| Uniprot Accession |
P43527,P29466
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Sepsis
|
| Disease from KEGG |
NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, Pathogenic Escherichia coli infection, Pertussis, Legionellosis, Yersinia infection, Influenza A, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSBTAG00000050239, ENSG00000137752
|
Pre-made viral vector of Caspase 1/CASP1 cDNA Clones/ORF Plasmid
Caspase 1/CASP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo834 | Pre-made Human CASP1/ICE/P45 siRNA oligo Duplex | 834 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25166 | Pre-made Rat Casp1/Ice/p45 siRNA oligo Duplex | 25166 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo514214 | Pre-made Bovines/Cattle CASP1 siRNA oligo Duplex | 514214 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
Caspase 1/CASP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T98269-Ab | Human | Anti-Human Caspase 1/CASP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T98269-Ab | Rat | Anti-Rat Caspase 1/CASP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T98269-Ab | Bovines/Cattle | Anti-Bovines/Cattle Caspase 1/CASP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
Caspase 1/CASP1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T98269-Ag | Human | Human Caspase 1/CASP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T98269-Ag | Rat | Rat Caspase 1/CASP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T98269-Ag | Bovines/Cattle | Bovines/Cattle Caspase 1/CASP1 recombinant protein | Mammalian cell | Detail |
