PTPN6 Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore PTPN6 gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Target ID GM-T98264
Target Name PTPN6
Gene Group ldentifer
(Target Gene ID in Homo species)
5777
Gene ID 100052882 (Equus caballus), 101087073 (Felis catus), 116689 (Rattus norvegicus), 15170 (Mus musculus)
486717 (Canis lupus familiaris), 512312 (Bos taurus), 5777 (Homo sapiens), 714374 (Macaca mulatta)
Target Alternative Names 70Z-SHP,DRPLA,HCP,HCPH,HPTP1C,Hcph,Hematopoietic cell protein-tyrosine phosphatase,PTP-1C,PTPN6,PTPTY-42,Protein-tyrosine phosphatase 1C (PTP-1C),Protein-tyrosine phosphatase SHP-1,Ptp1C,Ptph6,Ptpn6,SH-PTP1,SHP-1,SHP-1L,SHP1,Shp-1,Tyrosine-protein phosphatase non-receptor type 6,hcp,me
Uniprot Accession P81718,P29351,P29350
Protein Sub-location Introcelluar Protein
Category Therapeutics Target
Disease cancer
Disease from KEGG Adherens junction, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Pathogenic Escherichia coli infection, Leishmaniasis, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer
Gene Ensembl ENSECAG00000000465, ENSMUSG00000004266, ENSCAFG00845026107, ENSBTAG00000020294, ENSG00000111679, ENSMMUG00000010203
Target Classification Kinase, Tumor-associated antigen (TAA)


Pre-made viral vector of PTPN6 cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP002023Human PTPN6/HCP/HCPH Lentivirus plasmidNM_0805485777HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLP002023Human PTPN6/HCP/HCPH Lentivirus particleNM_0805485777HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
pGMLPm002019Mouse Ptpn6/70Z-SHP/hcp Lentivirus plasmidNM_00107770515170MouseLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLPm002019Mouse Ptpn6/70Z-SHP/hcp Lentivirus particleNM_00107770515170MouseLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail


PTPN6 siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo5777Pre-made Human PTPN6/HCP/HCPH siRNA oligo Duplex5777HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo116689Pre-made Rat Ptpn6/Ptph6/Shp-1 siRNA oligo Duplex116689RatIn-vitro grade; in-vivo gradeDetail
pGMoligo15170Pre-made Mouse Ptpn6/me/hcp siRNA oligo Duplex15170MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo714374Pre-made Cynomolgus/Rhesus macaque PTPN6 siRNA oligo Duplex714374Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101087073Pre-made Cat/Feline PTPN6 siRNA oligo Duplex101087073Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo486717Pre-made Dog/Canine PTPN6/DRPLA siRNA oligo Duplex486717Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo512312Pre-made Bovines/Cattle PTPN6 siRNA oligo Duplex512312Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100052882Pre-made Equine/Horse PTPN6 siRNA oligo Duplex100052882Equine/HorseIn-vitro grade; in-vivo gradeDetail


PTPN6 antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T98264-AbHumanAnti-Human PTPN6 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-rg-T98264-AbRatAnti-Rat PTPN6 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-mg-T98264-AbMouseAnti-Mouse PTPN6 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cynog-T98264-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque PTPN6 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-felg-T98264-AbCat/FelineAnti-Cat/Feline PTPN6 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-cang-T98264-AbDog/CanineAnti-Dog/Canine PTPN6 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-bovg-T98264-AbBovines/CattleAnti-Bovines/Cattle PTPN6 monoclonal antibodymabTherapeutics Target antibodyDetail
GM-Tg-equg-T98264-AbEquine/HorseAnti-Equine/Horse PTPN6 monoclonal antibodymabTherapeutics Target antibodyDetail


PTPN6 recombinant protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T98264-AgHumanHuman PTPN6 recombinant proteinMammalian cellDetail
GM-Tg-rg-T98264-AgRatRat PTPN6 recombinant proteinMammalian cellDetail
GM-Tg-mg-T98264-AgMouseMouse PTPN6 recombinant proteinMammalian cellDetail
GM-Tg-cynog-T98264-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque PTPN6 recombinant proteinMammalian cellDetail
GM-Tg-felg-T98264-AgCat/FelineCat/Feline PTPN6 recombinant proteinMammalian cellDetail
GM-Tg-cang-T98264-AgDog/CanineDog/Canine PTPN6 recombinant proteinMammalian cellDetail
GM-Tg-bovg-T98264-AgBovines/CattleBovines/Cattle PTPN6 recombinant proteinMammalian cellDetail
GM-Tg-equg-T98264-AgEquine/HorseEquine/Horse PTPN6 recombinant proteinMammalian cellDetail