Explore PTPN6 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T98264
|
| Target Name |
PTPN6
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5777
|
| Gene ID |
100052882 (Equus caballus), 101087073 (Felis catus), 116689 (Rattus norvegicus), 15170 (Mus musculus) 486717 (Canis lupus familiaris), 512312 (Bos taurus), 5777 (Homo sapiens), 714374 (Macaca mulatta)
|
| Target Alternative Names |
70Z-SHP,DRPLA,HCP,HCPH,HPTP1C,Hcph,Hematopoietic cell protein-tyrosine phosphatase,PTP-1C,PTPN6,PTPTY-42,Protein-tyrosine phosphatase 1C (PTP-1C),Protein-tyrosine phosphatase SHP-1,Ptp1C,Ptph6,Ptpn6,SH-PTP1,SHP-1,SHP-1L,SHP1,Shp-1,Tyrosine-protein phosphatase non-receptor type 6,hcp,me
|
| Uniprot Accession |
P81718,P29351,P29350
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Adherens junction, JAK-STAT signaling pathway, Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, B cell receptor signaling pathway, Pathogenic Escherichia coli infection, Leishmaniasis, Proteoglycans in cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
| Gene Ensembl |
ENSECAG00000000465, ENSMUSG00000004266, ENSCAFG00845026107, ENSBTAG00000020294, ENSG00000111679, ENSMMUG00000010203
|
| Target Classification |
Kinase, Tumor-associated antigen (TAA)
|
Pre-made viral vector of PTPN6 cDNA Clones/ORF Plasmid
PTPN6 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5777 | Pre-made Human PTPN6/HCP/HCPH siRNA oligo Duplex | 5777 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo116689 | Pre-made Rat Ptpn6/Ptph6/Shp-1 siRNA oligo Duplex | 116689 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo15170 | Pre-made Mouse Ptpn6/me/hcp siRNA oligo Duplex | 15170 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714374 | Pre-made Cynomolgus/Rhesus macaque PTPN6 siRNA oligo Duplex | 714374 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087073 | Pre-made Cat/Feline PTPN6 siRNA oligo Duplex | 101087073 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo486717 | Pre-made Dog/Canine PTPN6/DRPLA siRNA oligo Duplex | 486717 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo512312 | Pre-made Bovines/Cattle PTPN6 siRNA oligo Duplex | 512312 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100052882 | Pre-made Equine/Horse PTPN6 siRNA oligo Duplex | 100052882 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PTPN6 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T98264-Ab | Human | Anti-Human PTPN6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T98264-Ab | Rat | Anti-Rat PTPN6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T98264-Ab | Mouse | Anti-Mouse PTPN6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T98264-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PTPN6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T98264-Ab | Cat/Feline | Anti-Cat/Feline PTPN6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T98264-Ab | Dog/Canine | Anti-Dog/Canine PTPN6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T98264-Ab | Bovines/Cattle | Anti-Bovines/Cattle PTPN6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T98264-Ab | Equine/Horse | Anti-Equine/Horse PTPN6 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PTPN6 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T98264-Ag | Human | Human PTPN6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T98264-Ag | Rat | Rat PTPN6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T98264-Ag | Mouse | Mouse PTPN6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T98264-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PTPN6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T98264-Ag | Cat/Feline | Cat/Feline PTPN6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T98264-Ag | Dog/Canine | Dog/Canine PTPN6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T98264-Ag | Bovines/Cattle | Bovines/Cattle PTPN6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T98264-Ag | Equine/Horse | Equine/Horse PTPN6 recombinant protein | Mammalian cell | Detail |