Explore M6PR gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]
| Target ID |
GM-T97174
|
| Target Name |
M6PR
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4074
|
| Gene ID |
100061559 (Equus caballus), 101098389 (Felis catus), 17113 (Mus musculus), 281291 (Bos taurus)
312689 (Rattus norvegicus), 4074 (Homo sapiens), 477700 (Canis lupus familiaris), 716696 (Macaca mulatta)
|
| Target Alternative Names |
46 kDa mannose 6-phosphate receptor (MPR 46),CD Man-6-P receptor,CD-M6PR,CD-MPR,CDMPR,Cation-dependent mannose-6-phosphate receptor,M6PR,M6pr,MPR 46,MPR-46,MPR46,Mpr46,SMPR
|
| Uniprot Accession |
P24668,P11456,Q6AY20,P20645
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Lysosome, Phagosome
|
| Gene Ensembl |
ENSECAG00000021995, ENSMUSG00000007458, ENSBTAG00000018207, ENSG00000003056, ENSCAFG00845028694, ENSMMUG00000017846
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of M6PR cDNA Clones/ORF Plasmid
M6PR siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4074 | Pre-made Human M6PR/SMPR/MPR46 siRNA oligo Duplex | 4074 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo312689 | Pre-made Rat M6pr siRNA oligo Duplex | 312689 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17113 | Pre-made Mouse M6pr/Mpr46/CD-MPR siRNA oligo Duplex | 17113 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716696 | Pre-made Cynomolgus/Rhesus macaque M6PR siRNA oligo Duplex | 716696 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101098389 | Pre-made Cat/Feline M6PR siRNA oligo Duplex | 101098389 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477700 | Pre-made Dog/Canine M6PR siRNA oligo Duplex | 477700 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281291 | Pre-made Bovines/Cattle M6PR/CDMPR/CD-MPR siRNA oligo Duplex | 281291 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061559 | Pre-made Equine/Horse M6PR siRNA oligo Duplex | 100061559 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
M6PR antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T97174-Ab | Human | Anti-Human M6PR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T97174-Ab | Rat | Anti-Rat M6PR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T97174-Ab | Mouse | Anti-Mouse M6PR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T97174-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque M6PR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T97174-Ab | Cat/Feline | Anti-Cat/Feline M6PR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T97174-Ab | Dog/Canine | Anti-Dog/Canine M6PR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T97174-Ab | Bovines/Cattle | Anti-Bovines/Cattle M6PR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T97174-Ab | Equine/Horse | Anti-Equine/Horse M6PR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
M6PR VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T97174-Ag | Human | Human M6PR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T97174-Ag | Rat | Rat M6PR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T97174-Ag | Mouse | Mouse M6PR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T97174-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque M6PR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T97174-Ag | Cat/Feline | Cat/Feline M6PR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T97174-Ag | Dog/Canine | Dog/Canine M6PR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T97174-Ag | Bovines/Cattle | Bovines/Cattle M6PR VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T97174-Ag | Equine/Horse | Equine/Horse M6PR VLP (virus-like particle) | HEK293 | Products Developing |
