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Target
sublocation: Secreted Protein/Potential Cytokines.
This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression of this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Sep 2014]
| Target ID |
GM-T96005
|
| Target Name |
CXCL1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2919
|
| Gene ID |
2919 (Homo sapiens), 574222 (Macaca mulatta)
|
| Target Alternative Names |
C-X-C motif chemokine 1,CXCL1,FSP,GRO-alpha(1-73),GRO1,GROa,Growth-regulated alpha protein,MGSA,MGSA-a,Melanoma growth stimulatory activity (MGSA),NAP-3,Neutrophil-activating protein 3 (NAP-3),SCYB1
|
| Uniprot Accession |
P09341
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target, Cytokine Target
|
| Disease |
cancer, Prostate Cancer, Malignant neoplasm of bladder
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, NF-kappa B signaling pathway, NOD-like receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Alcoholic liver disease, Epithelial cell signaling in Helicobacter pylori infection, Legionellosis, Amoebiasis, Kaposi sarcoma-associated herpesvirus infection, Rheumatoid arthritis, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSG00000163739, ENSMMUG00000008367
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CXCL1 cDNA Clones/ORF Plasmid
CXCL1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2919 | Pre-made Human CXCL1/FSP/GRO1 siRNA oligo Duplex | 2919 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574222 | Pre-made Cynomolgus/Rhesus macaque CXCL1 siRNA oligo Duplex | 574222 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
CXCL1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T96005-Ab | Human | Anti-Human CXCL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T96005-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CXCL1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CXCL1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T96005-Ag | Human | Human CXCL1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T96005-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CXCL1 recombinant protein | Mammalian cell | Detail |
