Explore TWIST1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. [provided by RefSeq, Jul 2020]
| Target ID |
GM-T95660
|
| Target Name |
TWIST1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7291
|
| Gene ID |
100272214 (Equus caballus), 101094007 (Felis catus), 119866614 (Canis lupus familiaris), 22160 (Mus musculus) 574278 (Macaca mulatta), 7291 (Homo sapiens), 782170 (Bos taurus), 85489 (Rattus norvegicus)
|
| Target Alternative Names |
ACS3,BPES2,BPES3,CRS,CRS1,CSO,Class A basic helix-loop-helix protein 38 (bHLHa38),H-twist,M-Twist,Pde,SCS,SWCOS,Ska10,Ska,TWIST,TWIST1,Twist,Twist-related protein 1,Twist1,bHLHa38,pdt
|
| Uniprot Accession |
P26687,Q15672
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Proteoglycans in cancer
|
| Gene Ensembl |
ENSECAG00000033207, ENSCAFG00845007076, ENSMUSG00000035799, ENSG00000122691, ENSBTAG00000046922
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of TWIST1 cDNA Clones/ORF Plasmid
TWIST1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7291 | Pre-made Human TWIST1/CRS/CSO siRNA oligo Duplex | 7291 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo85489 | Pre-made Rat Twist1/Twist siRNA oligo Duplex | 85489 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22160 | Pre-made Mouse Twist1/Pde/pdt siRNA oligo Duplex | 22160 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574278 | Pre-made Cynomolgus/Rhesus macaque TWIST1 siRNA oligo Duplex | 574278 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101094007 | Pre-made Cat/Feline TWIST1 siRNA oligo Duplex | 101094007 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo119866614 | Pre-made Dog/Canine TWIST1 siRNA oligo Duplex | 119866614 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo782170 | Pre-made Bovines/Cattle TWIST1 siRNA oligo Duplex | 782170 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100272214 | Pre-made Equine/Horse TWIST1 siRNA oligo Duplex | 100272214 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TWIST1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T95660-Ab | Human | Anti-Human TWIST1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T95660-Ab | Rat | Anti-Rat TWIST1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T95660-Ab | Mouse | Anti-Mouse TWIST1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T95660-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TWIST1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T95660-Ab | Cat/Feline | Anti-Cat/Feline TWIST1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T95660-Ab | Dog/Canine | Anti-Dog/Canine TWIST1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T95660-Ab | Bovines/Cattle | Anti-Bovines/Cattle TWIST1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T95660-Ab | Equine/Horse | Anti-Equine/Horse TWIST1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
TWIST1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T95660-Ag | Human | Human TWIST1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T95660-Ag | Rat | Rat TWIST1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T95660-Ag | Mouse | Mouse TWIST1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T95660-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TWIST1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T95660-Ag | Cat/Feline | Cat/Feline TWIST1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T95660-Ag | Dog/Canine | Dog/Canine TWIST1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T95660-Ag | Bovines/Cattle | Bovines/Cattle TWIST1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T95660-Ag | Equine/Horse | Equine/Horse TWIST1 recombinant protein | Mammalian cell | Detail |