Explore NEDD4 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016]
| Target ID |
GM-T94980
|
| Target Name |
NEDD4
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4734
|
| Gene ID |
100054735 (Equus caballus), 101085214 (Felis catus), 17999 (Mus musculus), 25489 (Rattus norvegicus)
4734 (Homo sapiens), 507781 (Bos taurus), 608738 (Canis lupus familiaris), 699550 (Macaca mulatta)
|
| Target Alternative Names |
NEDD4,Nedd4,Gm7265,Nedd4a,Nedd4-1,EG639396,KIAA0093,E430025J12Rik,RPF1,NEDD4-1
|
| Uniprot Accession |
P46935,Q62940,P46934
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Tight junction, Epstein-Barr virus infection
|
| Gene Ensembl |
ENSECAG00000009456, ENSMUSG00000032216, ENSG00000069869, ENSBTAG00000013793, ENSCAFG00845029105, ENSMMUG00000008112
|
| Target Classification |
|
Pre-made viral vector of NEDD4 cDNA Clones/ORF Plasmid
NEDD4 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4734 | Pre-made Human NEDD4/RPF1/NEDD4-1 siRNA oligo Duplex | 4734 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25489 | Pre-made Rat Nedd4/Nedd4a siRNA oligo Duplex | 25489 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo17999 | Pre-made Mouse Nedd4/Gm7265/Nedd4a siRNA oligo Duplex | 17999 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699550 | Pre-made Cynomolgus/Rhesus macaque NEDD4 siRNA oligo Duplex | 699550 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101085214 | Pre-made Cat/Feline NEDD4 siRNA oligo Duplex | 101085214 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo608738 | Pre-made Dog/Canine NEDD4 siRNA oligo Duplex | 608738 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507781 | Pre-made Bovines/Cattle NEDD4 siRNA oligo Duplex | 507781 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100054735 | Pre-made Equine/Horse NEDD4 siRNA oligo Duplex | 100054735 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
NEDD4 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T94980-Ab | Human | Anti-Human NEDD4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T94980-Ab | Rat | Anti-Rat NEDD4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T94980-Ab | Mouse | Anti-Mouse NEDD4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T94980-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque NEDD4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T94980-Ab | Cat/Feline | Anti-Cat/Feline NEDD4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T94980-Ab | Dog/Canine | Anti-Dog/Canine NEDD4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T94980-Ab | Bovines/Cattle | Anti-Bovines/Cattle NEDD4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T94980-Ab | Equine/Horse | Anti-Equine/Horse NEDD4 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
NEDD4 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T94980-Ag | Human | Human NEDD4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T94980-Ag | Rat | Rat NEDD4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T94980-Ag | Mouse | Mouse NEDD4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T94980-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque NEDD4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T94980-Ag | Cat/Feline | Cat/Feline NEDD4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T94980-Ag | Dog/Canine | Dog/Canine NEDD4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T94980-Ag | Bovines/Cattle | Bovines/Cattle NEDD4 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T94980-Ag | Equine/Horse | Equine/Horse NEDD4 recombinant protein | Mammalian cell | Detail |
