Explore CHM gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
| Target ID |
GM-T90628
|
| Target Name |
CHM
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1121
|
| Gene ID |
100072281 (Equus caballus), 101095320 (Felis catus), 1121 (Homo sapiens), 12662 (Mus musculus)
24942 (Rattus norvegicus), 480972 (Canis lupus familiaris), 519552 (Bos taurus), 694499 (Macaca mulatta)
|
| Target Alternative Names |
CHM,Chm,TCD,GGTA,REP-1,DXS540,HSD-32,Rep-1
|
| Uniprot Accession |
P24386,Q9QXG2,P37727
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000019201, ENSG00000188419, ENSMUSG00000025531, ENSCAFG00845024883, ENSBTAG00000009598, ENSMMUG00000016776
|
| Target Classification |
|
CHM siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1121 | Pre-made Human CHM/TCD/GGTA siRNA oligo Duplex | 1121 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24942 | Pre-made Rat Chm siRNA oligo Duplex | 24942 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12662 | Pre-made Mouse Chm/Rep-1 siRNA oligo Duplex | 12662 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo694499 | Pre-made Cynomolgus/Rhesus macaque CHM siRNA oligo Duplex | 694499 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095320 | Pre-made Cat/Feline CHM siRNA oligo Duplex | 101095320 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480972 | Pre-made Dog/Canine CHM siRNA oligo Duplex | 480972 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo519552 | Pre-made Bovines/Cattle CHM siRNA oligo Duplex | 519552 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100072281 | Pre-made Equine/Horse CHM siRNA oligo Duplex | 100072281 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CHM antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T90628-Ab | Human | Anti-Human CHM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T90628-Ab | Rat | Anti-Rat CHM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T90628-Ab | Mouse | Anti-Mouse CHM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T90628-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CHM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T90628-Ab | Cat/Feline | Anti-Cat/Feline CHM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T90628-Ab | Dog/Canine | Anti-Dog/Canine CHM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T90628-Ab | Bovines/Cattle | Anti-Bovines/Cattle CHM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T90628-Ab | Equine/Horse | Anti-Equine/Horse CHM monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CHM recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T90628-Ag | Human | Human CHM recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T90628-Ag | Rat | Rat CHM recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T90628-Ag | Mouse | Mouse CHM recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T90628-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CHM recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T90628-Ag | Cat/Feline | Cat/Feline CHM recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T90628-Ag | Dog/Canine | Dog/Canine CHM recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T90628-Ag | Bovines/Cattle | Bovines/Cattle CHM recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T90628-Ag | Equine/Horse | Equine/Horse CHM recombinant protein | Mammalian cell | Detail |
