Recombinant multi-species CHM protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CHM protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia; also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
The Alternative Names of target: CHM,Rab proteins geranylgeranyltransferase component A 1,Choroideremia protein, Rab escort protein 1 (REP-1), TCD protein,TCD,GGTA,REP-1,DXS540,HSD-32

Target products collectionGo to CHM products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T90628-Ab-1/ GM-Tg-hg-T90628-Ab-2 Human CHM protein Human
GM-Tg-rg-T90628-Ab-1/ GM-Tg-rg-T90628-Ab-2 Rat CHM protein Rat
GM-Tg-mg-T90628-Ab-1/ GM-Tg-mg-T90628-Ab-2 Mouse CHM protein Mouse
GM-Tg-cynog-T90628-Ab-1/ GM-Tg-cynog-T90628-Ab-2 Cynomolgus/Rhesus macaque CHM monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T90628-Ab-1/ GM-Tg-felg-T90628-Ab-2 Feline CHM protein Feline
GM-Tg-cang-T90628-Ab-1/ GM-Tg-cang-T90628-Ab-2 Canine CHM protein Canine
GM-Tg-bovg-T90628-Ab-1/ GM-Tg-bovg-T90628-Ab-2 Bovine CHM protein Bovine
GM-Tg-equg-T90628-Ab-1/ GM-Tg-equg-T90628-Ab-2 Equine CHM protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T90628-Ab-1/ GM-Tg-hg-T90628-Ab-2; GM-Tg-rg-T90628-Ab-1/ GM-Tg-rg-T90628-Ab-2;
GM-Tg-mg-T90628-Ab-1/ GM-Tg-mg-T90628-Ab-2; GM-Tg-cynog-T90628-Ab-1/ GM-Tg-cynog-T90628-Ab-2;
GM-Tg-felg-T90628-Ab-1/ GM-Tg-felg-T90628-Ab-2; GM-Tg-cang-T90628-Ab-1/ GM-Tg-cang-T90628-Ab-2;
GM-Tg-bovg-T90628-Ab-1/ GM-Tg-bovg-T90628-Ab-2; GM-Tg-equg-T90628-Ab-1/ GM-Tg-equg-T90628-Ab-2
Products Name CHM protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CHM
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CHM protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.