Explore CD3/CD3E/CD3e gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T87075
|
| Target Name |
CD3/CD3E/CD3e
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
916
|
| Gene ID |
100629532 (Equus caballus), 12501 (Mus musculus), 281054 (Bos taurus), 315609 (Rattus norvegicus)
442981 (Canis lupus familiaris), 493936 (Felis catus), 699467 (Macaca mulatta), 916 (Homo sapiens)
|
| Target Alternative Names |
CD3,CD3E,CD3e,CD3epsilon,Cd3e,IMD18,T-cell surface antigen T3/Leu-4 epsilon chain,T-cell surface glycoprotein CD3 epsilon chain,T3E,T3e,TCRE
|
| Uniprot Accession |
P22646,Q28073,P27597,Q5R1Q1,P07766
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease from KEGG |
Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Chagas disease, Measles, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, PD-L1 expression and PD-1 checkpoint pathway in cancer
|
| Gene Ensembl |
ENSECAG00000014635, ENSMUSG00000032093, ENSBTAG00000015710, ENSCAFG00845002518, ENSMMUG00000017593, ENSG00000198851
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of CD3/CD3E/CD3e cDNA Clones/ORF Plasmid
CD3/CD3E/CD3e siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo916 | Pre-made Human CD3E/T3E/TCRE siRNA oligo Duplex | 916 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo315609 | Pre-made Rat Cd3e siRNA oligo Duplex | 315609 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12501 | Pre-made Mouse Cd3e/CD3/T3e siRNA oligo Duplex | 12501 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo699467 | Pre-made Cynomolgus/Rhesus macaque CD3E siRNA oligo Duplex | 699467 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo493936 | Pre-made Cat/Feline CD3E siRNA oligo Duplex | 493936 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo442981 | Pre-made Dog/Canine CD3E siRNA oligo Duplex | 442981 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281054 | Pre-made Bovines/Cattle CD3E siRNA oligo Duplex | 281054 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100629532 | Pre-made Equine/Horse CD3E siRNA oligo Duplex | 100629532 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CD3/CD3E/CD3e antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T87075-Ab | Human | Anti-Human CD3/CD3E/CD3e monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T87075-Ab | Rat | Anti-Rat CD3/CD3E/CD3e monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T87075-Ab | Mouse | Anti-Mouse CD3/CD3E/CD3e monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T87075-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CD3/CD3E/CD3e monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T87075-Ab | Cat/Feline | Anti-Cat/Feline CD3/CD3E/CD3e monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T87075-Ab | Dog/Canine | Anti-Dog/Canine CD3/CD3E/CD3e monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T87075-Ab | Bovines/Cattle | Anti-Bovines/Cattle CD3/CD3E/CD3e monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T87075-Ab | Equine/Horse | Anti-Equine/Horse CD3/CD3E/CD3e monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
CD3/CD3E/CD3e VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T87075-Ag | Human | Human CD3/CD3E/CD3e VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T87075-Ag | Rat | Rat CD3/CD3E/CD3e VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T87075-Ag | Mouse | Mouse CD3/CD3E/CD3e VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T87075-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CD3/CD3E/CD3e VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T87075-Ag | Cat/Feline | Cat/Feline CD3/CD3E/CD3e VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T87075-Ag | Dog/Canine | Dog/Canine CD3/CD3E/CD3e VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T87075-Ag | Bovines/Cattle | Bovines/Cattle CD3/CD3E/CD3e VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T87075-Ag | Equine/Horse | Equine/Horse CD3/CD3E/CD3e VLP (virus-like particle) | HEK293 | Products Developing |
