Explore LONP1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a mitochondrial matrix protein that belongs to the Lon family of ATP-dependent proteases. This protein mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides in the mitochondrial matrix. It may also have a chaperone function in the assembly of inner membrane protein complexes, and participate in the regulation of mitochondrial gene expression and maintenance of the integrity of the mitochondrial genome. Decreased expression of this gene has been noted in a patient with hereditary spastic paraplegia (PMID:18378094). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2013]
| Target ID |
GM-T86773
|
| Target Name |
LONP1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
9361
|
| Gene ID |
100065045 (Equus caballus), 101093417 (Felis catus), 170916 (Rattus norvegicus), 510796 (Bos taurus)
611425 (Canis lupus familiaris), 700284 (Macaca mulatta), 74142 (Mus musculus), 9361 (Homo sapiens)
|
| Target Alternative Names |
1200017E13Rik,CODASS,LON,LONHs,LONP,LONP1,Lon,Lon protease homolog,Lon protease-like protein (LONP),LonHS,Lonp1,Mitochondrial ATP-dependent protease Lon,PIM1,PRSS15,Prss15,Serine protease 15,hLON,mitochondrial
|
| Uniprot Accession |
Q924S5,Q59HJ6,Q8CGK3,P36776
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Gene Ensembl |
ENSECAG00000014761, ENSBTAG00000001795, ENSCAFG00845012796, ENSMMUG00000020707, ENSMUSG00000041168, ENSG00000196365
|
Pre-made viral vector of LONP1 cDNA Clones/ORF Plasmid
LONP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo9361 | Pre-made Human LONP1/LON/LONP siRNA oligo Duplex | 9361 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo170916 | Pre-made Rat Lonp1/Lon/Prss15 siRNA oligo Duplex | 170916 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo74142 | Pre-made Mouse Lonp1/LON/Prss15 siRNA oligo Duplex | 74142 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo700284 | Pre-made Cynomolgus/Rhesus macaque LONP1/PRSS15 siRNA oligo Duplex | 700284 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093417 | Pre-made Cat/Feline LONP1 siRNA oligo Duplex | 101093417 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo611425 | Pre-made Dog/Canine LONP1 siRNA oligo Duplex | 611425 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo510796 | Pre-made Bovines/Cattle LONP1/PRSS15 siRNA oligo Duplex | 510796 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065045 | Pre-made Equine/Horse LONP1 siRNA oligo Duplex | 100065045 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
LONP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T86773-Ab | Human | Anti-Human LONP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T86773-Ab | Rat | Anti-Rat LONP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T86773-Ab | Mouse | Anti-Mouse LONP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T86773-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque LONP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T86773-Ab | Cat/Feline | Anti-Cat/Feline LONP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T86773-Ab | Dog/Canine | Anti-Dog/Canine LONP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T86773-Ab | Bovines/Cattle | Anti-Bovines/Cattle LONP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T86773-Ab | Equine/Horse | Anti-Equine/Horse LONP1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
LONP1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T86773-Ag | Human | Human LONP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T86773-Ag | Rat | Rat LONP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T86773-Ag | Mouse | Mouse LONP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T86773-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque LONP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T86773-Ag | Cat/Feline | Cat/Feline LONP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T86773-Ag | Dog/Canine | Dog/Canine LONP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T86773-Ag | Bovines/Cattle | Bovines/Cattle LONP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T86773-Ag | Equine/Horse | Equine/Horse LONP1 recombinant protein | Mammalian cell | Detail |
