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Target
sublocation: Introcelluar Protein.
Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T86591
|
| Target Name |
PPARA
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5465
|
| Gene ID |
100049840 (Equus caballus), 101095837 (Felis catus), 19013 (Mus musculus), 25747 (Rattus norvegicus) 281992 (Bos taurus), 403654 (Canis lupus familiaris), 5465 (Homo sapiens), 613250 (Macaca mulatta)
|
| Target Alternative Names |
4933429D07Rik,NR1C1,Nr1c1,Nuclear receptor subfamily 1 group C member 1,PPAR,PPAR-alpha,PPARA,PPARalpha,Peroxisome proliferator-activated receptor alpha,Ppar,Ppara,hPPAR
|
| Uniprot Accession |
P23204,P37230,Q95N78,Q07869
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
PPAR signaling pathway, cAMP signaling pathway, Adipocytokine signaling pathway, Insulin resistance, Alcoholic liver disease, Hepatitis C, Chemical carcinogenesis - receptor activation
|
| Gene Ensembl |
ENSECAG00000000484, ENSMUSG00000022383, ENSBTAG00000008063, ENSCAFG00845010405, ENSG00000186951, ENSMMUG00000016258
|
| Target Classification |
Nuclear Receptors
|
Pre-made viral vector of PPARA cDNA Clones/ORF Plasmid
PPARA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5465 | Pre-made Human PPARA/PPAR/NR1C1 siRNA oligo Duplex | 5465 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25747 | Pre-made Rat Ppara/PPAR siRNA oligo Duplex | 25747 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19013 | Pre-made Mouse Ppara/Ppar/Nr1c1 siRNA oligo Duplex | 19013 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo613250 | Pre-made Cynomolgus/Rhesus macaque PPARA siRNA oligo Duplex | 613250 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095837 | Pre-made Cat/Feline PPARA siRNA oligo Duplex | 101095837 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403654 | Pre-made Dog/Canine PPARA siRNA oligo Duplex | 403654 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281992 | Pre-made Bovines/Cattle PPARA/PPARalpha siRNA oligo Duplex | 281992 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100049840 | Pre-made Equine/Horse PPARA siRNA oligo Duplex | 100049840 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PPARA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T86591-Ab | Human | Anti-Human PPARA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T86591-Ab | Rat | Anti-Rat PPARA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T86591-Ab | Mouse | Anti-Mouse PPARA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T86591-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PPARA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T86591-Ab | Cat/Feline | Anti-Cat/Feline PPARA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T86591-Ab | Dog/Canine | Anti-Dog/Canine PPARA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T86591-Ab | Bovines/Cattle | Anti-Bovines/Cattle PPARA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T86591-Ab | Equine/Horse | Anti-Equine/Horse PPARA monoclonal antibody | mab | Therapeutics Target antibody | Detail |
PPARA recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T86591-Ag | Human | Human PPARA recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T86591-Ag | Rat | Rat PPARA recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T86591-Ag | Mouse | Mouse PPARA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T86591-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PPARA recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T86591-Ag | Cat/Feline | Cat/Feline PPARA recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T86591-Ag | Dog/Canine | Dog/Canine PPARA recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T86591-Ag | Bovines/Cattle | Bovines/Cattle PPARA recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T86591-Ag | Equine/Horse | Equine/Horse PPARA recombinant protein | Mammalian cell | Detail |