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Target
sublocation: Introcelluar Protein.
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
| Target ID |
GM-T86528
|
| Target Name |
FDPS
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2224
|
| Gene ID |
100063641 (Equus caballus), 101086533 (Felis catus), 110196 (Mus musculus), 2224 (Homo sapiens) 281156 (Bos taurus), 480129 (Canis lupus familiaris), 717761 (Macaca mulatta), 83791 (Rattus norvegicus)
|
| Target Alternative Names |
(2E,6030492I17Rik,6E)-farnesyl diphosphate synthase,Ac2-125,Dimethylallyltranstransferase,FDPS,FPP synthase,FPPS,FPS,Farnesyl diphosphate synthase,Farnesyl pyrophosphate synthase,Fdps,Fdpsl1,Geranyltranstransferase,POROK9,mKIAA1293
|
| Uniprot Accession |
Q920E5,P14324,Q8WMY2,P05369
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways, Influenza A, Human T-cell leukemia virus 1 infection
|
| Gene Ensembl |
ENSECAG00000039158, ENSMUSG00000059743, ENSG00000160752, ENSBTAG00000003948, ENSCAFG00845011910, ENSMMUG00000023144
|
| Target Classification |
Kinase
|
Pre-made viral vector of FDPS cDNA Clones/ORF Plasmid
FDPS siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2224 | Pre-made Human FDPS/FPS/FPPS siRNA oligo Duplex | 2224 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo83791 | Pre-made Rat Fdps/FPS/Ac2-125 siRNA oligo Duplex | 83791 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo110196 | Pre-made Mouse Fdps/Fdpsl1/mKIAA1293 siRNA oligo Duplex | 110196 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo717761 | Pre-made Cynomolgus/Rhesus macaque FDPS siRNA oligo Duplex | 717761 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101086533 | Pre-made Cat/Feline FDPS siRNA oligo Duplex | 101086533 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480129 | Pre-made Dog/Canine FDPS siRNA oligo Duplex | 480129 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281156 | Pre-made Bovines/Cattle FDPS siRNA oligo Duplex | 281156 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100063641 | Pre-made Equine/Horse FDPS siRNA oligo Duplex | 100063641 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FDPS antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T86528-Ab | Human | Anti-Human FDPS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T86528-Ab | Rat | Anti-Rat FDPS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T86528-Ab | Mouse | Anti-Mouse FDPS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T86528-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FDPS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T86528-Ab | Cat/Feline | Anti-Cat/Feline FDPS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T86528-Ab | Dog/Canine | Anti-Dog/Canine FDPS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T86528-Ab | Bovines/Cattle | Anti-Bovines/Cattle FDPS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T86528-Ab | Equine/Horse | Anti-Equine/Horse FDPS monoclonal antibody | mab | Therapeutics Target antibody | Detail |
FDPS recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T86528-Ag | Human | Human FDPS recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T86528-Ag | Rat | Rat FDPS recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T86528-Ag | Mouse | Mouse FDPS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T86528-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FDPS recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T86528-Ag | Cat/Feline | Cat/Feline FDPS recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T86528-Ag | Dog/Canine | Dog/Canine FDPS recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T86528-Ag | Bovines/Cattle | Bovines/Cattle FDPS recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T86528-Ag | Equine/Horse | Equine/Horse FDPS recombinant protein | Mammalian cell | Detail |