Explore JAB1/COPS5 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T84791
|
| Target Name |
JAB1/COPS5
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
10987
|
| Gene ID |
100051846 (Equus caballus), 101092084 (Felis catus), 10987 (Homo sapiens), 26754 (Mus musculus)
312916 (Rattus norvegicus), 477901 (Canis lupus familiaris), 507179 (Bos taurus), 704584 (Macaca mulatta)
|
| Target Alternative Names |
COP9 signalosome complex subunit 5,COPS5,CSN5,Cops5,JAB1,Jab1,Jun activation domain-binding protein 1,MOV-34,Mov34,SGN5,Sgn5,Signalosome subunit 5
|
| Uniprot Accession |
Q92905,O35864
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
|
| Gene Ensembl |
ENSECAG00000013916, ENSG00000121022, ENSMUSG00000025917, ENSCAFG00845020562, ENSBTAG00000002784, ENSMMUG00000006281
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of JAB1/COPS5 cDNA Clones/ORF Plasmid
JAB1/COPS5 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo10987 | Pre-made Human COPS5/CSN5/JAB1 siRNA oligo Duplex | 10987 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo312916 | Pre-made Rat Cops5 siRNA oligo Duplex | 312916 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo26754 | Pre-made Mouse Cops5/CSN5/Jab1 siRNA oligo Duplex | 26754 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo704584 | Pre-made Cynomolgus/Rhesus macaque COPS5 siRNA oligo Duplex | 704584 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092084 | Pre-made Cat/Feline COPS5 siRNA oligo Duplex | 101092084 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo477901 | Pre-made Dog/Canine COPS5 siRNA oligo Duplex | 477901 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507179 | Pre-made Bovines/Cattle COPS5 siRNA oligo Duplex | 507179 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100051846 | Pre-made Equine/Horse COPS5 siRNA oligo Duplex | 100051846 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
JAB1/COPS5 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T84791-Ab | Human | Anti-Human JAB1/COPS5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T84791-Ab | Rat | Anti-Rat JAB1/COPS5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T84791-Ab | Mouse | Anti-Mouse JAB1/COPS5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T84791-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque JAB1/COPS5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T84791-Ab | Cat/Feline | Anti-Cat/Feline JAB1/COPS5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T84791-Ab | Dog/Canine | Anti-Dog/Canine JAB1/COPS5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T84791-Ab | Bovines/Cattle | Anti-Bovines/Cattle JAB1/COPS5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T84791-Ab | Equine/Horse | Anti-Equine/Horse JAB1/COPS5 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
JAB1/COPS5 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T84791-Ag | Human | Human JAB1/COPS5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T84791-Ag | Rat | Rat JAB1/COPS5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T84791-Ag | Mouse | Mouse JAB1/COPS5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T84791-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque JAB1/COPS5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T84791-Ag | Cat/Feline | Cat/Feline JAB1/COPS5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T84791-Ag | Dog/Canine | Dog/Canine JAB1/COPS5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T84791-Ag | Bovines/Cattle | Bovines/Cattle JAB1/COPS5 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T84791-Ag | Equine/Horse | Equine/Horse JAB1/COPS5 recombinant protein | Mammalian cell | Detail |
