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Target
sublocation: Introcelluar Protein.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T84560
|
| Target Name |
UCP2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7351
|
| Gene ID |
22228 (Mus musculus), 281562 (Bos taurus), 403576 (Canis lupus familiaris), 54315 (Rattus norvegicus) 574198 (Macaca mulatta), 692194 (Felis catus), 7351 (Homo sapiens)
|
| Target Alternative Names |
BMIQ4,Dicarboxylate carrier SLC25A8,Mitochondrial uncoupling protein 2 (UCP 2),SLC25A8,Slc25a8,Solute carrier family 25 member 8,UCP 2,UCP2,UCPH,Ucp2
|
| Uniprot Accession |
P70406,Q3SZI5,Q9N2J1,P56500,P55851
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Gene Ensembl |
ENSMUSG00000033685, ENSBTAG00000003692, ENSCAFG00845007207, ENSMMUG00000002605, ENSG00000175567
|
Pre-made viral vector of UCP2 cDNA Clones/ORF Plasmid
UCP2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7351 | Pre-made Human UCP2/UCPH/BMIQ4 siRNA oligo Duplex | 7351 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54315 | Pre-made Rat Ucp2 siRNA oligo Duplex | 54315 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22228 | Pre-made Mouse Ucp2/UCPH/UCP 2 siRNA oligo Duplex | 22228 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574198 | Pre-made Cynomolgus/Rhesus macaque UCP2 siRNA oligo Duplex | 574198 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo692194 | Pre-made Cat/Feline UCP2 siRNA oligo Duplex | 692194 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403576 | Pre-made Dog/Canine UCP2 siRNA oligo Duplex | 403576 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281562 | Pre-made Bovines/Cattle UCP2 siRNA oligo Duplex | 281562 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
UCP2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T84560-Ab | Human | Anti-Human UCP2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T84560-Ab | Rat | Anti-Rat UCP2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T84560-Ab | Mouse | Anti-Mouse UCP2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T84560-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque UCP2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T84560-Ab | Cat/Feline | Anti-Cat/Feline UCP2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T84560-Ab | Dog/Canine | Anti-Dog/Canine UCP2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T84560-Ab | Bovines/Cattle | Anti-Bovines/Cattle UCP2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
UCP2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T84560-Ag | Human | Human UCP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T84560-Ag | Rat | Rat UCP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T84560-Ag | Mouse | Mouse UCP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T84560-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque UCP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T84560-Ag | Cat/Feline | Cat/Feline UCP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T84560-Ag | Dog/Canine | Dog/Canine UCP2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T84560-Ag | Bovines/Cattle | Bovines/Cattle UCP2 recombinant protein | Mammalian cell | Detail |