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Target
sublocation: Transmembrane Protein.
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020]
| Target ID |
GM-T83611
|
| Target Name |
HLA-DRB1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
3123
|
| Gene ID |
3123 (Homo sapiens)
|
| Target Alternative Names |
DRB1,DRB1 beta chain,HLA class II histocompatibility antigen,HLA-DR1B,HLA-DRB,HLA-DRB1,Human leukocyte antigen DRB1 (HLA-DRB1),SS1
|
| Uniprot Accession |
P01911
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Phagosome, Cell adhesion molecules, Antigen processing and presentation, Hematopoietic cell lineage, Th1 and Th2 cell differentiation, Th17 cell differentiation, Intestinal immune network for IgA production, Type I diabetes mellitus, Leishmaniasis, Toxoplasmosis, Staphylococcus aureus infection, Tuberculosis, Influenza A, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Asthma, Autoimmune thyroid disease, Inflammatory bowel disease, Rheumatoid arthritis, Allograft rejection, Graft-versus-host disease, Viral myocarditis
|
| Gene Ensembl |
ENSG00000196126
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of HLA-DRB1 cDNA Clones/ORF Plasmid
HLA-DRB1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3123 | Pre-made Human HLA-DRB1/SS1/DRB1 siRNA oligo Duplex | 3123 | Human | In-vitro grade; in-vivo grade | Detail |
HLA-DRB1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T83611-Ab | Human | Anti-Human HLA-DRB1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
HLA-DRB1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T83611-Ag | Human | Human HLA-DRB1 VLP (virus-like particle) | HEK293 | Products Developing |
