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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]
| Target ID |
GM-T83192
|
| Target Name |
CNTF
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1270
|
| Gene ID |
100629778 (Equus caballus), 100848228 (Bos taurus), 101097592 (Felis catus), 1270 (Homo sapiens) 12803 (Mus musculus), 25707 (Rattus norvegicus), 483464 (Canis lupus familiaris), 701907 (Macaca mulatta)
|
| Target Alternative Names |
CNTF,Ciliary neurotrophic factor,Cntf,HCNTF
|
| Uniprot Accession |
P26441,P51642,P20294
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, JAK-STAT signaling pathway
|
| Gene Ensembl |
ENSBTAG00000003624, ENSG00000242689, ENSMUSG00000079415, ENSCAFG00845018289
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CNTF cDNA Clones/ORF Plasmid
CNTF siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1270 | Pre-made Human CNTF/HCNTF siRNA oligo Duplex | 1270 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25707 | Pre-made Rat Cntf siRNA oligo Duplex | 25707 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12803 | Pre-made Mouse Cntf siRNA oligo Duplex | 12803 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo701907 | Pre-made Cynomolgus/Rhesus macaque CNTF siRNA oligo Duplex | 701907 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097592 | Pre-made Cat/Feline CNTF siRNA oligo Duplex | 101097592 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483464 | Pre-made Dog/Canine CNTF siRNA oligo Duplex | 483464 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100848228 | Pre-made Bovines/Cattle CNTF siRNA oligo Duplex | 100848228 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100629778 | Pre-made Equine/Horse CNTF siRNA oligo Duplex | 100629778 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CNTF antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T83192-Ab | Human | Anti-Human CNTF monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T83192-Ab | Rat | Anti-Rat CNTF monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T83192-Ab | Mouse | Anti-Mouse CNTF monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T83192-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CNTF monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T83192-Ab | Cat/Feline | Anti-Cat/Feline CNTF monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T83192-Ab | Dog/Canine | Anti-Dog/Canine CNTF monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T83192-Ab | Bovines/Cattle | Anti-Bovines/Cattle CNTF monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T83192-Ab | Equine/Horse | Anti-Equine/Horse CNTF monoclonal antibody | mab | Therapeutics Target antibody, Cytokine antibody | Detail |
CNTF recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T83192-Ag | Human | Human CNTF recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T83192-Ag | Rat | Rat CNTF recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T83192-Ag | Mouse | Mouse CNTF recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T83192-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CNTF recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T83192-Ag | Cat/Feline | Cat/Feline CNTF recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T83192-Ag | Dog/Canine | Dog/Canine CNTF recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T83192-Ag | Bovines/Cattle | Bovines/Cattle CNTF recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T83192-Ag | Equine/Horse | Equine/Horse CNTF recombinant protein | Mammalian cell | Detail |