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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T82297
|
| Target Name |
FOLR2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2350
|
| Gene ID |
101095853 (Felis catus), 14276 (Mus musculus), 2350 (Homo sapiens), 293154 (Rattus norvegicus)
507672 (Bos taurus), 718405 (Macaca mulatta)
|
| Target Alternative Names |
BETA-HFR,FBP,FBP/PL-1,FBP2,FOLR1,FOLR2,FR-BETA,FR-P3,FR-beta,FRbeta,Folate receptor,Folate receptor 2,Folate receptor beta,Folbp-2,Folbp2,Folr2,Placental folate-binding protein (FBP),fetal/placental
|
| Uniprot Accession |
Q05685,P14207
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
|
| Disease from KEGG |
Antifolate resistance
|
| Gene Ensembl |
ENSMUSG00000032725, ENSG00000165457, ENSBTAG00000027684, ENSMMUG00000010453
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of FOLR2 cDNA Clones/ORF Plasmid
FOLR2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2350 | Pre-made Human FOLR2/FBP/FOLR1 siRNA oligo Duplex | 2350 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo293154 | Pre-made Rat Folr2 siRNA oligo Duplex | 293154 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14276 | Pre-made Mouse Folr2/FBP2/FR-P3 siRNA oligo Duplex | 14276 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo718405 | Pre-made Cynomolgus/Rhesus macaque FOLR2 siRNA oligo Duplex | 718405 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101095853 | Pre-made Cat/Feline FOLR2 siRNA oligo Duplex | 101095853 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo507672 | Pre-made Bovines/Cattle FOLR2 siRNA oligo Duplex | 507672 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
FOLR2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T82297-Ab | Human | Anti-Human FOLR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T82297-Ab | Rat | Anti-Rat FOLR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T82297-Ab | Mouse | Anti-Mouse FOLR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T82297-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FOLR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T82297-Ab | Cat/Feline | Anti-Cat/Feline FOLR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T82297-Ab | Bovines/Cattle | Anti-Bovines/Cattle FOLR2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
FOLR2 VLP (virus-like particle)
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T82297-Ag | Human | Human FOLR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T82297-Ag | Rat | Rat FOLR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T82297-Ag | Mouse | Mouse FOLR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T82297-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FOLR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T82297-Ag | Cat/Feline | Cat/Feline FOLR2 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T82297-Ag | Bovines/Cattle | Bovines/Cattle FOLR2 VLP (virus-like particle) | HEK293 | Products Developing |
