ITCH Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore ITCH gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Introcelluar Protein.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]

Target ID	GM-T81240
Target Name	ITCH
Gene Group ldentifer （Target Gene ID in Homo species)	83737
Gene ID	100069340 (Equus caballus), 101086133 (Felis catus), 16396 (Mus musculus), 311567 (Rattus norvegicus) 477199 (Canis lupus familiaris), 508431 (Bos taurus), 707640 (Macaca mulatta), 83737 (Homo sapiens)
Target Alternative Names	6720481N21Rik,8030492O04Rik,A130065M08,ADMFD,AIF4,AIP4,Atrophin-1-interacting protein 4 (AIP4),C230047C07Rik,E3 ubiquitin-protein ligase Itchy homolog,HECT-type E3 ubiquitin transferase Itchy homolog,ITCH,Itch,NAPP1,NFE2-associated polypeptide 1 (NAPP1)
Uniprot Accession	Q8C863,Q96J02
Protein Sub-location	Introcelluar Protein
Category	Therapeutics Target
Disease	cancer
Disease from KEGG	TNF signaling pathway
Gene Ensembl	ENSECAG00000016216, ENSMUSG00000027598, ENSCAFG00845015881, ENSBTAG00000000308, ENSMMUG00000012912, ENSG00000078747
Target Classification	Tumor-associated antigen (TAA)

Pre-made viral vector of ITCH cDNA Clones/ORF Plasmid

Cat No.	Product Name	NMID	GeneID	Species	Type	Marker	Fusion Tag	Promoter	Detail
pGMLV000051	Human ITCH/AIF4/AIP4 Lentivirus plasmid	NM_031483.4	83737	Human	Lentivirus plasmid	ZsGreen	Null	CMV	Detail
pGMAD001304	Human ITCH/ADMFD/AIF4 Adenovirus plasmid	NM_001257137.3	83737	Human	Adenovirus plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMPC001096	Human ITCH/ADMFD/AIF4 Mammalian (Non-Viral Vector) plasmid	NM_001257137.3	83737	Human	Mammalian (Non-Viral Vector) plasmid	Null	HA (C-Terminal)	CMV	Detail
vGMLV000051	Human ITCH/AIF4/AIP4 Lentivirus particle	NM_031483.4	83737	Human	Lentivirus particle	ZsGreen	Null	CMV	Detail
vGMAD001304	Human ITCH/ADMFD/AIF4 Adenovirus particle	NM_001257137.3	83737	Human	Adenovirus particle	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMAD000722	Mouse Itch/6720481N21Rik/8030492O04Rik Adenovirus plasmid	NM_001243712	16396	Mouse	Adenovirus plasmid	EGFP	3xflag (C-Terminal)	EF1	Detail
pGMAAV001307	Mouse Itch/6720481N21Rik/8030492O04Rik Adeno-associate virus(AAV) plasmid	NM_001243712.1	16396	Mouse	Adeno-associate virus(AAV) plasmid	Null	3xflag (C-Terminal)	Ksp-cadherin	Detail
pGMLPm003580	Mouse Itch/6720481N21Rik/8030492O04Rik Lentivirus plasmid	NM_001243712	16396	Mouse	Lentivirus plasmid	ZsGreen	3xflag (C-Terminal)	CMV	Detail
vGMAD000722	Mouse Itch/6720481N21Rik/8030492O04Rik Adenovirus particle	NM_001243712	16396	Mouse	Adenovirus particle	EGFP	3xflag (C-Terminal)	EF1	Detail
vGMAAV001307	Mouse Itch/6720481N21Rik/8030492O04Rik Adeno-associate virus(AAV) particle	NM_001243712.1	16396	Mouse	Adeno-associate virus(AAV) particle	Null	3xflag (C-Terminal)	Ksp-cadherin	Detail
vGMLPm003580	Mouse Itch/6720481N21Rik/8030492O04Rik Lentivirus particle	NM_001243712	16396	Mouse	Lentivirus particle	ZsGreen	3xflag (C-Terminal)	CMV	Detail

ITCH siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.	Product Name	GeneID	Species	Grade	Detail
pGMoligo83737	Pre-made Human ITCH/AIF4/AIP4 siRNA oligo Duplex	83737	Human	In-vitro grade; in-vivo grade	Detail
pGMoligo311567	Pre-made Rat Itch siRNA oligo Duplex	311567	Rat	In-vitro grade; in-vivo grade	Detail
pGMoligo16396	Pre-made Mouse Itch/AIP4/A130065M08 siRNA oligo Duplex	16396	Mouse	In-vitro grade; in-vivo grade	Detail
pGMoligo707640	Pre-made Cynomolgus/Rhesus macaque ITCH siRNA oligo Duplex	707640	Cynomolgus/Rhesus macaque	In-vitro grade; in-vivo grade	Detail
pGMoligo101086133	Pre-made Cat/Feline ITCH siRNA oligo Duplex	101086133	Cat/Feline	In-vitro grade; in-vivo grade	Detail
pGMoligo477199	Pre-made Dog/Canine ITCH siRNA oligo Duplex	477199	Dog/Canine	In-vitro grade; in-vivo grade	Detail
pGMoligo508431	Pre-made Bovines/Cattle ITCH siRNA oligo Duplex	508431	Bovines/Cattle	In-vitro grade; in-vivo grade	Detail
pGMoligo100069340	Pre-made Equine/Horse ITCH siRNA oligo Duplex	100069340	Equine/Horse	In-vitro grade; in-vivo grade	Detail

ITCH antibody/GMab

Cat No.	Species	Antibody Name	Format	Classified by tag	Detail
GM-Tg-hg-T81240-Ab	Human	Anti-Human ITCH monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-rg-T81240-Ab	Rat	Anti-Rat ITCH monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-mg-T81240-Ab	Mouse	Anti-Mouse ITCH monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-cynog-T81240-Ab	Cynomolgus/Rhesus macaque	Anti-Cynomolgus/Rhesus macaque ITCH monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-felg-T81240-Ab	Cat/Feline	Anti-Cat/Feline ITCH monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-cang-T81240-Ab	Dog/Canine	Anti-Dog/Canine ITCH monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-bovg-T81240-Ab	Bovines/Cattle	Anti-Bovines/Cattle ITCH monoclonal antibody	mab	Therapeutics Target antibody	Detail
GM-Tg-equg-T81240-Ab	Equine/Horse	Anti-Equine/Horse ITCH monoclonal antibody	mab	Therapeutics Target antibody	Detail

ITCH recombinant protein

Cat No.	Species	Antigen Name	Expression Platform	Detail
GM-Tg-hg-T81240-Ag	Human	Human ITCH recombinant protein	Mammalian cell	Detail
GM-Tg-rg-T81240-Ag	Rat	Rat ITCH recombinant protein	Mammalian cell	Detail
GM-Tg-mg-T81240-Ag	Mouse	Mouse ITCH recombinant protein	Mammalian cell	Detail
GM-Tg-cynog-T81240-Ag	Cynomolgus/Rhesus macaque	Cynomolgus/Rhesus macaque ITCH recombinant protein	Mammalian cell	Detail
GM-Tg-felg-T81240-Ag	Cat/Feline	Cat/Feline ITCH recombinant protein	Mammalian cell	Detail
GM-Tg-cang-T81240-Ag	Dog/Canine	Dog/Canine ITCH recombinant protein	Mammalian cell	Detail
GM-Tg-bovg-T81240-Ag	Bovines/Cattle	Bovines/Cattle ITCH recombinant protein	Mammalian cell	Detail
GM-Tg-equg-T81240-Ag	Equine/Horse	Equine/Horse ITCH recombinant protein	Mammalian cell	Detail