Recombinant multi-species ITCH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ITCH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
The Alternative Names of target: ITCH,E3 ubiquitin-protein ligase Itchy homolog,Itch,Atrophin-1-interacting protein 4 (AIP4), HECT-type E3 ubiquitin transferase Itchy homolog, NFE2-associated polypeptide 1 (NAPP1),AIF4,AIP4,ADMFD,NAPP1

Target products collectionGo to ITCH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T81240-Ab-1/ GM-Tg-hg-T81240-Ab-2 Human ITCH protein Human
GM-Tg-rg-T81240-Ab-1/ GM-Tg-rg-T81240-Ab-2 Rat ITCH protein Rat
GM-Tg-mg-T81240-Ab-1/ GM-Tg-mg-T81240-Ab-2 Mouse ITCH protein Mouse
GM-Tg-cynog-T81240-Ab-1/ GM-Tg-cynog-T81240-Ab-2 Cynomolgus/Rhesus macaque ITCH monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T81240-Ab-1/ GM-Tg-felg-T81240-Ab-2 Feline ITCH protein Feline
GM-Tg-cang-T81240-Ab-1/ GM-Tg-cang-T81240-Ab-2 Canine ITCH protein Canine
GM-Tg-bovg-T81240-Ab-1/ GM-Tg-bovg-T81240-Ab-2 Bovine ITCH protein Bovine
GM-Tg-equg-T81240-Ab-1/ GM-Tg-equg-T81240-Ab-2 Equine ITCH protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T81240-Ab-1/ GM-Tg-hg-T81240-Ab-2; GM-Tg-rg-T81240-Ab-1/ GM-Tg-rg-T81240-Ab-2;
GM-Tg-mg-T81240-Ab-1/ GM-Tg-mg-T81240-Ab-2; GM-Tg-cynog-T81240-Ab-1/ GM-Tg-cynog-T81240-Ab-2;
GM-Tg-felg-T81240-Ab-1/ GM-Tg-felg-T81240-Ab-2; GM-Tg-cang-T81240-Ab-1/ GM-Tg-cang-T81240-Ab-2;
GM-Tg-bovg-T81240-Ab-1/ GM-Tg-bovg-T81240-Ab-2; GM-Tg-equg-T81240-Ab-1/ GM-Tg-equg-T81240-Ab-2
Products Name ITCH protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ITCH
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ITCH protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.