Explore calreticulin/CALR gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]
| Target ID |
GM-T79821
|
| Target Name |
calreticulin/CALR
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
811
|
| Gene ID |
100064107 (Equus caballus), 101087384 (Felis catus), 12317 (Mus musculus), 281036 (Bos taurus)
476694 (Canis lupus familiaris), 64202 (Rattus norvegicus), 716910 (Macaca mulatta), 811 (Homo sapiens)
|
| Target Alternative Names |
CALR,CALR1,CRP55,CRT,Calr,Calregulin,Calreticulin,ERp60,Endoplasmic reticulum resident protein 60 (ERp60),HACBP,HEL-S-99n,RO,SSA,cC1qR,calreticulin,grp60
|
| Uniprot Accession |
P14211,P52193,P28490,P18418,P27797
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
Prostate Cancer, Malignant neoplasm of bladder
|
| Disease from KEGG |
Protein processing in endoplasmic reticulum, Phagosome, Antigen processing and presentation, Chagas disease, Human cytomegalovirus infection, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection
|
| Gene Ensembl |
ENSECAG00000008164, ENSMUSG00000003814, ENSBTAG00000015114, ENSCAFG00845015220, ENSMMUG00000004392, ENSG00000179218
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of calreticulin/CALR cDNA Clones/ORF Plasmid
calreticulin/CALR siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo811 | Pre-made Human CALR/RO/CRT siRNA oligo Duplex | 811 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo64202 | Pre-made Rat Calr siRNA oligo Duplex | 64202 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12317 | Pre-made Mouse Calr/CRT/Calregulin siRNA oligo Duplex | 12317 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716910 | Pre-made Cynomolgus/Rhesus macaque CALR/CRP55 siRNA oligo Duplex | 716910 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101087384 | Pre-made Cat/Feline CALR siRNA oligo Duplex | 101087384 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476694 | Pre-made Dog/Canine CALR/CRP55/ERp60 siRNA oligo Duplex | 476694 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281036 | Pre-made Bovines/Cattle CALR siRNA oligo Duplex | 281036 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100064107 | Pre-made Equine/Horse CALR siRNA oligo Duplex | 100064107 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
calreticulin/CALR antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T79821-Ab | Human | Anti-Human calreticulin/CALR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T79821-Ab | Rat | Anti-Rat calreticulin/CALR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T79821-Ab | Mouse | Anti-Mouse calreticulin/CALR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T79821-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque calreticulin/CALR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T79821-Ab | Cat/Feline | Anti-Cat/Feline calreticulin/CALR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T79821-Ab | Dog/Canine | Anti-Dog/Canine calreticulin/CALR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T79821-Ab | Bovines/Cattle | Anti-Bovines/Cattle calreticulin/CALR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T79821-Ab | Equine/Horse | Anti-Equine/Horse calreticulin/CALR monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
calreticulin/CALR recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T79821-Ag | Human | Human calreticulin/CALR recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T79821-Ag | Rat | Rat calreticulin/CALR recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T79821-Ag | Mouse | Mouse calreticulin/CALR recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T79821-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque calreticulin/CALR recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T79821-Ag | Cat/Feline | Cat/Feline calreticulin/CALR recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T79821-Ag | Dog/Canine | Dog/Canine calreticulin/CALR recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T79821-Ag | Bovines/Cattle | Bovines/Cattle calreticulin/CALR recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T79821-Ag | Equine/Horse | Equine/Horse calreticulin/CALR recombinant protein | Mammalian cell | Detail |
