Explore ADORA2A gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
| Target ID |
GM-T77365
|
| Target Name |
ADORA2A
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
135
|
| Gene ID |
100034039 (Equus caballus), 101080742 (Felis catus), 11540 (Mus musculus), 135 (Homo sapiens) 25369 (Rattus norvegicus), 403960 (Canis lupus familiaris), 617828 (Bos taurus), 707865 (Macaca mulatta)
|
| Target Alternative Names |
A2AAR,A2aR,A2ar,AA2AR,ADENO,ADORA2,ADORA2A,ARA2A,Adenosine receptor A2a,Adora2a,Adora2l1,RDC8
|
| Uniprot Accession |
Q6TLI7,Q60613,P29274,P30543,P11617
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease from KEGG |
Rap1 signaling pathway, Calcium signaling pathway, cAMP signaling pathway, Neuroactive ligand-receptor interaction, Vascular smooth muscle contraction
|
| Gene Ensembl |
ENSECAG00000034739, ENSMUSG00000020178, ENSG00000128271, ENSCAFG00845022393, ENSBTAG00000016944, ENSMMUG00000008516
|
| Target Classification |
GPCR, Checkpoint-Immuno Oncology
|
Pre-made viral vector of ADORA2A cDNA Clones/ORF Plasmid
ADORA2A siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo135 | Pre-made Human ADORA2A/A2aR/RDC8 siRNA oligo Duplex | 135 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25369 | Pre-made Rat Adora2a/A2ar/ADENO siRNA oligo Duplex | 25369 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11540 | Pre-made Mouse Adora2a/A2aR/A2AAR siRNA oligo Duplex | 11540 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo707865 | Pre-made Cynomolgus/Rhesus macaque ADORA2A siRNA oligo Duplex | 707865 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101080742 | Pre-made Cat/Feline ADORA2A siRNA oligo Duplex | 101080742 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403960 | Pre-made Dog/Canine ADORA2A siRNA oligo Duplex | 403960 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo617828 | Pre-made Bovines/Cattle ADORA2A siRNA oligo Duplex | 617828 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034039 | Pre-made Equine/Horse ADORA2A siRNA oligo Duplex | 100034039 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ADORA2A antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T77365-Ab | Human | Anti-Human ADORA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T77365-Ab | Rat | Anti-Rat ADORA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T77365-Ab | Mouse | Anti-Mouse ADORA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T77365-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ADORA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T77365-Ab | Cat/Feline | Anti-Cat/Feline ADORA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T77365-Ab | Dog/Canine | Anti-Dog/Canine ADORA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T77365-Ab | Bovines/Cattle | Anti-Bovines/Cattle ADORA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T77365-Ab | Equine/Horse | Anti-Equine/Horse ADORA2A monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
ADORA2A VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T77365-Ag | Human | Human ADORA2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T77365-Ag | Rat | Rat ADORA2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T77365-Ag | Mouse | Mouse ADORA2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T77365-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ADORA2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T77365-Ag | Cat/Feline | Cat/Feline ADORA2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T77365-Ag | Dog/Canine | Dog/Canine ADORA2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T77365-Ag | Bovines/Cattle | Bovines/Cattle ADORA2A VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T77365-Ag | Equine/Horse | Equine/Horse ADORA2A VLP (virus-like particle) | HEK293 | Products Developing |