Explore DBH gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]
Target ID |
GM-T74937
|
Target Name |
DBH
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1621
|
Gene ID |
101082957 (Felis catus), 13166 (Mus musculus), 1621 (Homo sapiens), 25699 (Rattus norvegicus) 280758 (Bos taurus), 448806 (Canis lupus familiaris), 574105 (Macaca mulatta), 791247 (Equus caballus)
|
Target Alternative Names |
DBH,Dbh,DBM,ORTHYP1,DOPBHY
|
Uniprot Accession |
Q64237,P09172,Q05754,P15101,Q68CI2,Q9XTA0
|
Uniprot Entry Name |
|
Protein Sub-location |
Secreted Protein/Potential Cytokines
|
Category |
Therapeutics Target
|
Disease |
|
Disease from KEGG |
Metabolic pathways
|
Gene Ensembl |
ENSMUSG00000000889, ENSG00000123454, ENSBTAG00000004508, ENSCAFG00845010802, ENSMMUG00000017207, ENSECAG00000019582
|
Target Classification |
|
DBH siRNA/miRNA/oligo for RNA interfence (RNAi)
Cat No. | Product Name | GeneID | Species | Grade | Detail |
---|
pGMoligo1621 | Pre-made Human DBH/DBM/ORTHYP1 siRNA oligo Duplex | 1621 | Human | In-vitro grade; in-vivo grade | Detail |
pGMoligo25699 | Pre-made Rat Dbh/DOPBHY siRNA oligo Duplex | 25699 | Rat | In-vitro grade; in-vivo grade | Detail |
pGMoligo13166 | Pre-made Mouse Dbh siRNA oligo Duplex | 13166 | Mouse | In-vitro grade; in-vivo grade | Detail |
pGMoligo574105 | Pre-made Cynomolgus/Rhesus macaque DBH siRNA oligo Duplex | 574105 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
pGMoligo101082957 | Pre-made Cat/Feline DBH siRNA oligo Duplex | 101082957 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
pGMoligo448806 | Pre-made Dog/Canine DBH siRNA oligo Duplex | 448806 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
pGMoligo280758 | Pre-made Bovines/Cattle DBH siRNA oligo Duplex | 280758 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
pGMoligo791247 | Pre-made Equine/Horse DBH siRNA oligo Duplex | 791247 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
DBH antibody/GMab
Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
---|
GM-Tg-hg-T74937-Ab | Human | Anti-Human DBH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-rg-T74937-Ab | Rat | Anti-Rat DBH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-mg-T74937-Ab | Mouse | Anti-Mouse DBH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cynog-T74937-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DBH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-felg-T74937-Ab | Cat/Feline | Anti-Cat/Feline DBH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-cang-T74937-Ab | Dog/Canine | Anti-Dog/Canine DBH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-bovg-T74937-Ab | Bovines/Cattle | Anti-Bovines/Cattle DBH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
GM-Tg-equg-T74937-Ab | Equine/Horse | Anti-Equine/Horse DBH monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
DBH recombinant protein
Cat No. | Species | Antigen Name | Expression Platform | Detail |
---|
GM-Tg-hg-T74937-Ag | Human | Human DBH recombinant protein | Mammalian cell | Detail |
GM-Tg-rg-T74937-Ag | Rat | Rat DBH recombinant protein | Mammalian cell | Detail |
GM-Tg-mg-T74937-Ag | Mouse | Mouse DBH recombinant protein | Mammalian cell | Detail |
GM-Tg-cynog-T74937-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DBH recombinant protein | Mammalian cell | Detail |
GM-Tg-felg-T74937-Ag | Cat/Feline | Cat/Feline DBH recombinant protein | Mammalian cell | Detail |
GM-Tg-cang-T74937-Ag | Dog/Canine | Dog/Canine DBH recombinant protein | Mammalian cell | Detail |
GM-Tg-bovg-T74937-Ag | Bovines/Cattle | Bovines/Cattle DBH recombinant protein | Mammalian cell | Detail |
GM-Tg-equg-T74937-Ag | Equine/Horse | Equine/Horse DBH recombinant protein | Mammalian cell | Detail |