Recombinant multi-species DBH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DBH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. The encoded protein, expressed in neuroscretory vesicles and chromaffin granules of the adrenal medulla, catalyzes the conversion of dopamine to norepinephrine, which functions as both a hormone and as the main neurotransmitter of the sympathetic nervous system. The enzyme encoded by this gene exists exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide. Mutations in this gene cause dopamine beta-hydroxylate deficiency in human patients, characterized by deficits in autonomic and cardiovascular function, including hypotension and ptosis. Polymorphisms in this gene may play a role in a variety of psychiatric disorders. [provided by RefSeq, Aug 2017]
The Alternative Names of target: DBH,Dopamine beta-hydroxylase,Dopamine beta-monooxygenase,DBM,ORTHYP1

Target products collectionGo to DBH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T74937-Ab-1/ GM-Tg-hg-T74937-Ab-2 Human DBH protein Human
GM-Tg-rg-T74937-Ab-1/ GM-Tg-rg-T74937-Ab-2 Rat DBH protein Rat
GM-Tg-mg-T74937-Ab-1/ GM-Tg-mg-T74937-Ab-2 Mouse DBH protein Mouse
GM-Tg-cynog-T74937-Ab-1/ GM-Tg-cynog-T74937-Ab-2 Cynomolgus/Rhesus macaque DBH monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T74937-Ab-1/ GM-Tg-felg-T74937-Ab-2 Feline DBH protein Feline
GM-Tg-cang-T74937-Ab-1/ GM-Tg-cang-T74937-Ab-2 Canine DBH protein Canine
GM-Tg-bovg-T74937-Ab-1/ GM-Tg-bovg-T74937-Ab-2 Bovine DBH protein Bovine
GM-Tg-equg-T74937-Ab-1/ GM-Tg-equg-T74937-Ab-2 Equine DBH protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T74937-Ab-1/ GM-Tg-hg-T74937-Ab-2; GM-Tg-rg-T74937-Ab-1/ GM-Tg-rg-T74937-Ab-2;
GM-Tg-mg-T74937-Ab-1/ GM-Tg-mg-T74937-Ab-2; GM-Tg-cynog-T74937-Ab-1/ GM-Tg-cynog-T74937-Ab-2;
GM-Tg-felg-T74937-Ab-1/ GM-Tg-felg-T74937-Ab-2; GM-Tg-cang-T74937-Ab-1/ GM-Tg-cang-T74937-Ab-2;
GM-Tg-bovg-T74937-Ab-1/ GM-Tg-bovg-T74937-Ab-2; GM-Tg-equg-T74937-Ab-1/ GM-Tg-equg-T74937-Ab-2
Products Name DBH protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DBH
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DBH protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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