Serpin C1/Antithrombin III/SERPINC1/ATIII Target & Gene Products-cDNA ORF clones/siRNA/antibody/protein

Explore Serpin C1/Antithrombin III/SERPINC1/ATIII gene products and cross-species research data at TarMart platform. Discover comprehensive biological information, expression tools, and therapeutic insights for Homo sapiens (human), Cynomolgus monkeys, rodents (mouse/rat), canines, felines, bovines, and equines. Your premier destination for multi-species gene research solutions
Target sublocation: Transmembrane Protein.
The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020]

Target ID GM-T73476
Target Name Serpin C1/Antithrombin III/SERPINC1/ATIII
Gene Group ldentifer
(Target Gene ID in Homo species)
462
Gene ID 100061173 (Equus caballus), 101093983 (Felis catus), 11905 (Mus musculus), 304917 (Rattus norvegicus)
462 (Homo sapiens), 480066 (Canis lupus familiaris), 540261 (Bos taurus), 708854 (Macaca mulatta)
Target Alternative Names AT3,AT3D,ATIII,ATIII-R2,ATIII-T1,ATIII-T2,Antithrombin III,Antithrombin-III,At-3,At3,SERPINC1,Serpin C1,Serpinc1,THPH7
Uniprot Accession P32261,P01008,P41361
Protein Sub-location Transmembrane Protein
Category Therapeutics Target
Disease cancer
Disease from KEGG Complement and coagulation cascades
Gene Ensembl ENSECAG00000014493, ENSMUSG00000026715, ENSG00000117601, ENSCAFG00845011264, ENSBTAG00000004362, ENSMMUG00000000629


Pre-made viral vector of Serpin C1/Antithrombin III/SERPINC1/ATIII cDNA Clones/ORF Plasmid

Cat No.Product NameNMIDGeneIDSpeciesTypeMarkerFusion TagPromoterDetail
pGMLP002891Human SERPINC1/AT3/AT3D Lentivirus plasmidNM_000488462HumanLentivirus plasmidZsGreen3xflag (C-Terminal)CMVDetail
pGMAAV000149Human SERPINC1/AT3/AT3D Adeno-associate virus(AAV) plasmidNM_000488.3462HumanAdeno-associate virus(AAV) plasmidGFP3xflag (C-Terminal)CMVDetail
pGMAAV000297Human SERPINC1/AT3/AT3D Adeno-associate virus(AAV) plasmidNM_000488.3462HumanAdeno-associate virus(AAV) plasmidFirefly luciferase3xflag (C-Terminal)TBGDetail
pGMAAV000501Human SERPINC1/AT3/AT3D Adeno-associate virus(AAV) plasmidNM_000488.3462HumanAdeno-associate virus(AAV) plasmidZsGreen3xflag (C-Terminal)CMVDetail
vGMLP002891Human SERPINC1/AT3/AT3D Lentivirus particleNM_000488462HumanLentivirus particleZsGreen3xflag (C-Terminal)CMVDetail
vGMAAV000149Human SERPINC1/AT3/AT3D Adeno-associate virus(AAV) particleNM_000488.3462HumanAdeno-associate virus(AAV) particleGFP3xflag (C-Terminal)CMVDetail
vGMAAV000297Human SERPINC1/AT3/AT3D Adeno-associate virus(AAV) particleNM_000488.3462HumanAdeno-associate virus(AAV) particleFirefly luciferase3xflag (C-Terminal)TBGDetail
vGMAAV000501Human SERPINC1/AT3/AT3D Adeno-associate virus(AAV) particleNM_000488.3462HumanAdeno-associate virus(AAV) particleZsGreen3xflag (C-Terminal)CMVDetail
pGMAD000029Rat Serpinc1 Adenovirus plasmidNM_001012027304917RatAdenovirus plasmidGFP3xflag (C-Terminal)EF1Detail
vGMAD000029Rat Serpinc1 Adenovirus particleNM_001012027304917RatAdenovirus particleGFP3xflag (C-Terminal)EF1Detail
pGMAAV000091Mouse Serpinc1/AI114908/At-3 Adeno-associate virus(AAV) plasmidNM_080844.411905MouseAdeno-associate virus(AAV) plasmidGFP3xflag (C-Terminal)CMVDetail
vGMAAV000091Mouse Serpinc1/AI114908/At-3 Adeno-associate virus(AAV) particleNM_080844.411905MouseAdeno-associate virus(AAV) particleGFP3xflag (C-Terminal)CMVDetail


Serpin C1/Antithrombin III/SERPINC1/ATIII siRNA/miRNA/oligo for RNA interfence (RNAi)

Cat No.Product NameGeneIDSpeciesGradeDetail
pGMoligo462Pre-made Human SERPINC1/AT3/AT3D siRNA oligo Duplex462HumanIn-vitro grade; in-vivo gradeDetail
pGMoligo304917Pre-made Rat Serpinc1 siRNA oligo Duplex304917RatIn-vitro grade; in-vivo gradeDetail
pGMoligo11905Pre-made Mouse Serpinc1/At3/At-3 siRNA oligo Duplex11905MouseIn-vitro grade; in-vivo gradeDetail
pGMoligo708854Pre-made Cynomolgus/Rhesus macaque SERPINC1 siRNA oligo Duplex708854Cynomolgus/Rhesus macaqueIn-vitro grade; in-vivo gradeDetail
pGMoligo101093983Pre-made Cat/Feline SERPINC1 siRNA oligo Duplex101093983Cat/FelineIn-vitro grade; in-vivo gradeDetail
pGMoligo480066Pre-made Dog/Canine SERPINC1 siRNA oligo Duplex480066Dog/CanineIn-vitro grade; in-vivo gradeDetail
pGMoligo540261Pre-made Bovines/Cattle SERPINC1/AT3 siRNA oligo Duplex540261Bovines/CattleIn-vitro grade; in-vivo gradeDetail
pGMoligo100061173Pre-made Equine/Horse SERPINC1/AT3 siRNA oligo Duplex100061173Equine/HorseIn-vitro grade; in-vivo gradeDetail


Serpin C1/Antithrombin III/SERPINC1/ATIII antibody/GMab

Cat No.SpeciesAntibody NameFormatClassified by tagDetail
GM-Tg-hg-T73476-AbHumanAnti-Human Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-rg-T73476-AbRatAnti-Rat Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-mg-T73476-AbMouseAnti-Mouse Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-cynog-T73476-AbCynomolgus/Rhesus macaqueAnti-Cynomolgus/Rhesus macaque Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-felg-T73476-AbCat/FelineAnti-Cat/Feline Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-cang-T73476-AbDog/CanineAnti-Dog/Canine Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-bovg-T73476-AbBovines/CattleAnti-Bovines/Cattle Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail
GM-Tg-equg-T73476-AbEquine/HorseAnti-Equine/Horse Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibodymabFACS/Biofunctional Antibody, Therapeutics Target antibodyDetail


Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)/protein

Cat No.SpeciesAntigen NameExpression PlatformDetail
GM-Tg-hg-T73476-AgHumanHuman Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)HEK293Products Developing
GM-Tg-rg-T73476-AgRatRat Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)HEK293Products Developing
GM-Tg-mg-T73476-AgMouseMouse Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)HEK293Products Developing
GM-Tg-cynog-T73476-AgCynomolgus/Rhesus macaqueCynomolgus/Rhesus macaque Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)HEK293Products Developing
GM-Tg-felg-T73476-AgCat/FelineCat/Feline Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)HEK293Products Developing
GM-Tg-cang-T73476-AgDog/CanineDog/Canine Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)HEK293Products Developing
GM-Tg-bovg-T73476-AgBovines/CattleBovines/Cattle Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)HEK293Products Developing
GM-Tg-equg-T73476-AgEquine/HorseEquine/Horse Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)HEK293Products Developing