Explore Serpin C1/Antithrombin III/SERPINC1/ATIII gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
The protein encoded by this gene, antithrombin III, is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Sep 2020]
| Target ID |
GM-T73476
|
| Target Name |
Serpin C1/Antithrombin III/SERPINC1/ATIII
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
462
|
| Gene ID |
100061173 (Equus caballus), 101093983 (Felis catus), 11905 (Mus musculus), 304917 (Rattus norvegicus) 462 (Homo sapiens), 480066 (Canis lupus familiaris), 540261 (Bos taurus), 708854 (Macaca mulatta)
|
| Target Alternative Names |
AT3,AT3D,ATIII,ATIII-R2,ATIII-T1,ATIII-T2,Antithrombin III,Antithrombin-III,At-3,At3,SERPINC1,Serpin C1,Serpinc1,THPH7
|
| Uniprot Accession |
P32261,P01008,P41361
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Complement and coagulation cascades
|
| Gene Ensembl |
ENSECAG00000014493, ENSMUSG00000026715, ENSG00000117601, ENSCAFG00845011264, ENSBTAG00000004362, ENSMMUG00000000629
|
Pre-made viral vector of Serpin C1/Antithrombin III/SERPINC1/ATIII cDNA Clones/ORF Plasmid
Serpin C1/Antithrombin III/SERPINC1/ATIII siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo462 | Pre-made Human SERPINC1/AT3/AT3D siRNA oligo Duplex | 462 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo304917 | Pre-made Rat Serpinc1 siRNA oligo Duplex | 304917 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11905 | Pre-made Mouse Serpinc1/At3/At-3 siRNA oligo Duplex | 11905 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708854 | Pre-made Cynomolgus/Rhesus macaque SERPINC1 siRNA oligo Duplex | 708854 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093983 | Pre-made Cat/Feline SERPINC1 siRNA oligo Duplex | 101093983 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo480066 | Pre-made Dog/Canine SERPINC1 siRNA oligo Duplex | 480066 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540261 | Pre-made Bovines/Cattle SERPINC1/AT3 siRNA oligo Duplex | 540261 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100061173 | Pre-made Equine/Horse SERPINC1/AT3 siRNA oligo Duplex | 100061173 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Serpin C1/Antithrombin III/SERPINC1/ATIII antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T73476-Ab | Human | Anti-Human Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T73476-Ab | Rat | Anti-Rat Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T73476-Ab | Mouse | Anti-Mouse Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T73476-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T73476-Ab | Cat/Feline | Anti-Cat/Feline Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T73476-Ab | Dog/Canine | Anti-Dog/Canine Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T73476-Ab | Bovines/Cattle | Anti-Bovines/Cattle Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T73476-Ab | Equine/Horse | Anti-Equine/Horse Serpin C1/Antithrombin III/SERPINC1/ATIII monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T73476-Ag | Human | Human Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T73476-Ag | Rat | Rat Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T73476-Ag | Mouse | Mouse Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T73476-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T73476-Ag | Cat/Feline | Cat/Feline Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T73476-Ag | Dog/Canine | Dog/Canine Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T73476-Ag | Bovines/Cattle | Bovines/Cattle Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T73476-Ag | Equine/Horse | Equine/Horse Serpin C1/Antithrombin III/SERPINC1/ATIII VLP (virus-like particle) | HEK293 | Products Developing |