Explore F3/Tissue Factor/Coagulation Factor III/CD142 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]
| Target ID |
GM-T72702
|
| Target Name |
F3/Tissue Factor/Coagulation Factor III/CD142
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2152
|
| Gene ID |
100058506 (Equus caballus), 101082330 (Felis catus), 14066 (Mus musculus), 2152 (Homo sapiens)
25584 (Rattus norvegicus), 280686 (Bos taurus), 490153 (Canis lupus familiaris), 714456 (Macaca mulatta)
|
| Target Alternative Names |
CD142,Cf-3,Cf3,Coagulation Factor III,Coagulation factor III,F3,TF,TFA,Thromboplastin,Tissue Factor,Tissue factor
|
| Uniprot Accession |
P20352,P13726,P42533,P30931
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index
|
| Disease from KEGG |
Complement and coagulation cascades, AGE-RAGE signaling pathway in diabetic complications
|
| Gene Ensembl |
ENSMUSG00000028128, ENSG00000117525, ENSBTAG00000007101, ENSCAFG00845014757, ENSMMUG00000056548
|
Pre-made viral vector of F3/Tissue Factor/Coagulation Factor III/CD142 cDNA Clones/ORF Plasmid
F3/Tissue Factor/Coagulation Factor III/CD142 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2152 | Pre-made Human F3/TF/TFA siRNA oligo Duplex | 2152 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25584 | Pre-made Rat F3/TF siRNA oligo Duplex | 25584 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14066 | Pre-made Mouse F3/TF/Cf3 siRNA oligo Duplex | 14066 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo714456 | Pre-made Cynomolgus/Rhesus macaque F3 siRNA oligo Duplex | 714456 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082330 | Pre-made Cat/Feline F3 siRNA oligo Duplex | 101082330 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo490153 | Pre-made Dog/Canine F3/TF siRNA oligo Duplex | 490153 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280686 | Pre-made Bovines/Cattle F3/TF siRNA oligo Duplex | 280686 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100058506 | Pre-made Equine/Horse F3 siRNA oligo Duplex | 100058506 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
F3/Tissue Factor/Coagulation Factor III/CD142 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T72702-Ab | Human | Anti-Human F3/Tissue Factor/Coagulation Factor III/CD142 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T72702-Ab | Rat | Anti-Rat F3/Tissue Factor/Coagulation Factor III/CD142 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T72702-Ab | Mouse | Anti-Mouse F3/Tissue Factor/Coagulation Factor III/CD142 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T72702-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque F3/Tissue Factor/Coagulation Factor III/CD142 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T72702-Ab | Cat/Feline | Anti-Cat/Feline F3/Tissue Factor/Coagulation Factor III/CD142 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T72702-Ab | Dog/Canine | Anti-Dog/Canine F3/Tissue Factor/Coagulation Factor III/CD142 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T72702-Ab | Bovines/Cattle | Anti-Bovines/Cattle F3/Tissue Factor/Coagulation Factor III/CD142 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T72702-Ab | Equine/Horse | Anti-Equine/Horse F3/Tissue Factor/Coagulation Factor III/CD142 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
F3/Tissue Factor/Coagulation Factor III/CD142 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T72702-Ag | Human | Human F3/Tissue Factor/Coagulation Factor III/CD142 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T72702-Ag | Rat | Rat F3/Tissue Factor/Coagulation Factor III/CD142 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T72702-Ag | Mouse | Mouse F3/Tissue Factor/Coagulation Factor III/CD142 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T72702-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque F3/Tissue Factor/Coagulation Factor III/CD142 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T72702-Ag | Cat/Feline | Cat/Feline F3/Tissue Factor/Coagulation Factor III/CD142 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T72702-Ag | Dog/Canine | Dog/Canine F3/Tissue Factor/Coagulation Factor III/CD142 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T72702-Ag | Bovines/Cattle | Bovines/Cattle F3/Tissue Factor/Coagulation Factor III/CD142 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T72702-Ag | Equine/Horse | Equine/Horse F3/Tissue Factor/Coagulation Factor III/CD142 VLP (virus-like particle) | HEK293 | Products Developing |
