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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
| Target ID |
GM-T72507
|
| Target Name |
Cyclin D3/CCND3
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
896
|
| Gene ID |
100066590 (Equus caballus), 101101311 (Felis catus), 12445 (Mus musculus), 25193 (Rattus norvegicus) 540547 (Bos taurus), 608847 (Canis lupus familiaris), 695215 (Macaca mulatta), 896 (Homo sapiens)
|
| Target Alternative Names |
9230106B05Rik,CCND3,Ccnd3,Cyclin D3,G1/S-specific cyclin-D3
|
| Uniprot Accession |
P30282,P48961,Q3MHH5,P30281
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
p53 signaling pathway, PI3K-Akt signaling pathway, Cellular senescence, Wnt signaling pathway, Hippo signaling pathway, Focal adhesion, JAK-STAT signaling pathway, Measles, Influenza A, Human papillomavirus infection, Human T-cell leukemia virus 1 infection, Epstein-Barr virus infection, Pathways in cancer, Chemical carcinogenesis - receptor activation
|
| Gene Ensembl |
ENSECAG00000023862, ENSMUSG00000034165, ENSBTAG00000010106, ENSCAFG00845016058, ENSMMUG00000004419, ENSG00000112576
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of Cyclin D3/CCND3 cDNA Clones/ORF Plasmid
Cyclin D3/CCND3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo896 | Pre-made Human CCND3 siRNA oligo Duplex | 896 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25193 | Pre-made Rat Ccnd3 siRNA oligo Duplex | 25193 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12445 | Pre-made Mouse Ccnd3/9230106B05Rik siRNA oligo Duplex | 12445 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695215 | Pre-made Cynomolgus/Rhesus macaque CCND3 siRNA oligo Duplex | 695215 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101311 | Pre-made Cat/Feline CCND3 siRNA oligo Duplex | 101101311 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo608847 | Pre-made Dog/Canine CCND3 siRNA oligo Duplex | 608847 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo540547 | Pre-made Bovines/Cattle CCND3 siRNA oligo Duplex | 540547 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100066590 | Pre-made Equine/Horse CCND3 siRNA oligo Duplex | 100066590 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Cyclin D3/CCND3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T72507-Ab | Human | Anti-Human Cyclin D3/CCND3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T72507-Ab | Rat | Anti-Rat Cyclin D3/CCND3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T72507-Ab | Mouse | Anti-Mouse Cyclin D3/CCND3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T72507-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Cyclin D3/CCND3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T72507-Ab | Cat/Feline | Anti-Cat/Feline Cyclin D3/CCND3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T72507-Ab | Dog/Canine | Anti-Dog/Canine Cyclin D3/CCND3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T72507-Ab | Bovines/Cattle | Anti-Bovines/Cattle Cyclin D3/CCND3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T72507-Ab | Equine/Horse | Anti-Equine/Horse Cyclin D3/CCND3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
Cyclin D3/CCND3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T72507-Ag | Human | Human Cyclin D3/CCND3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T72507-Ag | Rat | Rat Cyclin D3/CCND3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T72507-Ag | Mouse | Mouse Cyclin D3/CCND3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T72507-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Cyclin D3/CCND3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T72507-Ag | Cat/Feline | Cat/Feline Cyclin D3/CCND3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T72507-Ag | Dog/Canine | Dog/Canine Cyclin D3/CCND3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T72507-Ag | Bovines/Cattle | Bovines/Cattle Cyclin D3/CCND3 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T72507-Ag | Equine/Horse | Equine/Horse Cyclin D3/CCND3 recombinant protein | Mammalian cell | Detail |