Explore Cathepsin C/CTSC gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. [provided by RefSeq, Nov 2015]
| Target ID |
GM-T70490
|
| Target Name |
Cathepsin C/CTSC
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1075
|
| Gene ID |
100060401 (Equus caballus), 101092140 (Felis catus), 1075 (Homo sapiens), 13032 (Mus musculus) 25423 (Rattus norvegicus), 352958 (Bos taurus), 403458 (Canis lupus familiaris), 705320 (Macaca mulatta)
|
| Target Alternative Names |
CATC,CPPI,CTSC,CatC,Cathepsin C,Cathepsin J,Ctsc,DPP-I,DPP1,DPPI,DPPI),Dipeptidyl peptidase 1,Dipeptidyl peptidase I (DPP-I,Dipeptidyl transferase,HMS,JP,JPD,PALS,PDON1,PLS
|
| Uniprot Accession |
P53634,P97821,P80067,Q3ZCJ8,O97578
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Lysosome, Apoptosis
|
| Gene Ensembl |
ENSECAG00000020881, ENSG00000109861, ENSMUSG00000030560, ENSBTAG00000011100, ENSCAFG00845026305, ENSMMUG00000022139
|
Pre-made viral vector of Cathepsin C/CTSC cDNA Clones/ORF Plasmid
Cathepsin C/CTSC siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1075 | Pre-made Human CTSC/JP/HMS siRNA oligo Duplex | 1075 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25423 | Pre-made Rat Ctsc/CATC/DPPI siRNA oligo Duplex | 25423 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13032 | Pre-made Mouse Ctsc/CatC/DPP1 siRNA oligo Duplex | 13032 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo705320 | Pre-made Cynomolgus/Rhesus macaque CTSC siRNA oligo Duplex | 705320 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092140 | Pre-made Cat/Feline CTSC siRNA oligo Duplex | 101092140 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403458 | Pre-made Dog/Canine CTSC/DPPI/DPP-I siRNA oligo Duplex | 403458 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo352958 | Pre-made Bovines/Cattle CTSC siRNA oligo Duplex | 352958 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060401 | Pre-made Equine/Horse CTSC siRNA oligo Duplex | 100060401 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Cathepsin C/CTSC antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T70490-Ab | Human | Anti-Human Cathepsin C/CTSC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T70490-Ab | Rat | Anti-Rat Cathepsin C/CTSC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T70490-Ab | Mouse | Anti-Mouse Cathepsin C/CTSC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T70490-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Cathepsin C/CTSC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T70490-Ab | Cat/Feline | Anti-Cat/Feline Cathepsin C/CTSC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T70490-Ab | Dog/Canine | Anti-Dog/Canine Cathepsin C/CTSC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T70490-Ab | Bovines/Cattle | Anti-Bovines/Cattle Cathepsin C/CTSC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T70490-Ab | Equine/Horse | Anti-Equine/Horse Cathepsin C/CTSC monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Cathepsin C/CTSC recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T70490-Ag | Human | Human Cathepsin C/CTSC recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T70490-Ag | Rat | Rat Cathepsin C/CTSC recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T70490-Ag | Mouse | Mouse Cathepsin C/CTSC recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T70490-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Cathepsin C/CTSC recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T70490-Ag | Cat/Feline | Cat/Feline Cathepsin C/CTSC recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T70490-Ag | Dog/Canine | Dog/Canine Cathepsin C/CTSC recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T70490-Ag | Bovines/Cattle | Bovines/Cattle Cathepsin C/CTSC recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T70490-Ag | Equine/Horse | Equine/Horse Cathepsin C/CTSC recombinant protein | Mammalian cell | Detail |