Explore FGF8 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Secreted Protein/Potential Cytokines.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T69580
|
| Target Name |
FGF8
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
2253
|
| Gene ID |
100060309 (Equus caballus), 101084652 (Felis catus), 14179 (Mus musculus), 2253 (Homo sapiens) 29349 (Rattus norvegicus), 326284 (Bos taurus), 403868 (Canis lupus familiaris), 722394 (Macaca mulatta)
|
| Target Alternative Names |
AIGF,Aigf,Androgen-induced growth factor (AIGF),FGF-8,FGF6C,FGF8,Fgf-8,Fgf6c,Fgf8,Fibroblast growth factor 8,HBGF-8,HH6,Heparin-binding growth factor 8 (HBGF-8),KAL6
|
| Uniprot Accession |
P37237,P55075,O62682
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, PI3K-Akt signaling pathway, Regulation of actin cytoskeleton, Pathways in cancer, Chemical carcinogenesis - receptor activation, Melanoma, Breast cancer, Gastric cancer
|
| Gene Ensembl |
ENSMUSG00000025219, ENSG00000107831, ENSBTAG00000001530, ENSCAFG00845021086
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of FGF8 cDNA Clones/ORF Plasmid
FGF8 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2253 | Pre-made Human FGF8/HH6/AIGF siRNA oligo Duplex | 2253 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29349 | Pre-made Rat Fgf8/Fgf6c siRNA oligo Duplex | 29349 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14179 | Pre-made Mouse Fgf8/Aigf/Fgf-8 siRNA oligo Duplex | 14179 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo722394 | Pre-made Cynomolgus/Rhesus macaque FGF8 siRNA oligo Duplex | 722394 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084652 | Pre-made Cat/Feline FGF8 siRNA oligo Duplex | 101084652 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403868 | Pre-made Dog/Canine FGF8/AIGF/FGF-8 siRNA oligo Duplex | 403868 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo326284 | Pre-made Bovines/Cattle FGF8/FGF6C siRNA oligo Duplex | 326284 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100060309 | Pre-made Equine/Horse FGF8 siRNA oligo Duplex | 100060309 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FGF8 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T69580-Ab | Human | Anti-Human FGF8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T69580-Ab | Rat | Anti-Rat FGF8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T69580-Ab | Mouse | Anti-Mouse FGF8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T69580-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FGF8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T69580-Ab | Cat/Feline | Anti-Cat/Feline FGF8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T69580-Ab | Dog/Canine | Anti-Dog/Canine FGF8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T69580-Ab | Bovines/Cattle | Anti-Bovines/Cattle FGF8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T69580-Ab | Equine/Horse | Anti-Equine/Horse FGF8 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
FGF8 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T69580-Ag | Human | Human FGF8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T69580-Ag | Rat | Rat FGF8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T69580-Ag | Mouse | Mouse FGF8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T69580-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FGF8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T69580-Ag | Cat/Feline | Cat/Feline FGF8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T69580-Ag | Dog/Canine | Dog/Canine FGF8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T69580-Ag | Bovines/Cattle | Bovines/Cattle FGF8 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T69580-Ag | Equine/Horse | Equine/Horse FGF8 recombinant protein | Mammalian cell | Detail |