Explore CXCL11 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC. This antimicrobial gene is a CXC member of the chemokine superfamily. Its encoded protein induces a chemotactic response in activated T-cells and is the dominant ligand for CXC receptor-3. The gene encoding this protein contains 4 exons and at least three polyadenylation signals which might reflect cell-specific regulation of expression. IFN-gamma is a potent inducer of transcription of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
| Target ID |
GM-T68465
|
| Target Name |
CXCL11
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6373
|
| Gene ID |
100629807 (Equus caballus), 101099880 (Felis catus), 119867221 (Canis lupus familiaris), 305236 (Rattus norvegicus) 516104 (Bos taurus), 574372 (Macaca mulatta), 6373 (Homo sapiens)
|
| Target Alternative Names |
Beta-R1,C-X-C motif chemokine 11,CXCL11,Cxcl11,H174,I-TAC,IP-9,IP9,Interferon gamma-inducible protein 9 (IP-9),Interferon-inducible T-cell alpha chemoattractant (I-TAC),SCYB11,SCYB9B,Small-inducible cytokine B11,b-R1
|
| Uniprot Accession |
A9QWQ1,O14625
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Cytokine Target
|
| Disease |
cancer
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, Chemokine signaling pathway, Toll-like receptor signaling pathway
|
| Gene Ensembl |
ENSECAG00000012253, ENSBTAG00000063224, ENSMMUG00000053130, ENSG00000169248
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of CXCL11 cDNA Clones/ORF Plasmid
CXCL11 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6373 | Pre-made Human CXCL11/IP9/H174 siRNA oligo Duplex | 6373 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo305236 | Pre-made Rat Cxcl11/SCYB11 siRNA oligo Duplex | 305236 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574372 | Pre-made Cynomolgus/Rhesus macaque CXCL11 siRNA oligo Duplex | 574372 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101099880 | Pre-made Cat/Feline CXCL11 siRNA oligo Duplex | 101099880 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo119867221 | Pre-made Dog/Canine CXCL11 siRNA oligo Duplex | 119867221 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo516104 | Pre-made Bovines/Cattle CXCL11 siRNA oligo Duplex | 516104 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100629807 | Pre-made Equine/Horse CXCL11 siRNA oligo Duplex | 100629807 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
CXCL11 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T68465-Ab | Human | Anti-Human CXCL11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T68465-Ab | Rat | Anti-Rat CXCL11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T68465-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CXCL11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T68465-Ab | Cat/Feline | Anti-Cat/Feline CXCL11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T68465-Ab | Dog/Canine | Anti-Dog/Canine CXCL11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T68465-Ab | Bovines/Cattle | Anti-Bovines/Cattle CXCL11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T68465-Ab | Equine/Horse | Anti-Equine/Horse CXCL11 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
CXCL11 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T68465-Ag | Human | Human CXCL11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T68465-Ag | Rat | Rat CXCL11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T68465-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CXCL11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T68465-Ag | Cat/Feline | Cat/Feline CXCL11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T68465-Ag | Dog/Canine | Dog/Canine CXCL11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T68465-Ag | Bovines/Cattle | Bovines/Cattle CXCL11 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T68465-Ag | Equine/Horse | Equine/Horse CXCL11 recombinant protein | Mammalian cell | Detail |