Explore COX2/Cyclooxygenase 2/PTGS2/COX-2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. [provided by RefSeq, Feb 2009]
| Target ID |
GM-T66665
|
| Target Name |
COX2/Cyclooxygenase 2/PTGS2/COX-2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5743
|
| Gene ID |
100126581 (Felis catus), 19225 (Mus musculus), 282023 (Bos taurus), 29527 (Rattus norvegicus)
442942 (Canis lupus familiaris), 5743 (Homo sapiens), 716671 (Macaca mulatta), 791253 (Equus caballus)
|
| Target Alternative Names |
COX-2,COX2,Cox-2,Cox2,Cyclooxygenase 2,Cyclooxygenase-2 (COX-2),GRIPGHS,PES-2,PGG/HS,PGH2S,PGHS-2,PGHS-2),PGHS2,PHS II,PHS-2,PTGS2,Pghs2,Prostaglandin G/H synthase 2,Prostaglandin H2 synthase 2 (PGH synthase 2,Prostaglandin-endoperoxide synthase 2,Ptgs2,TIS10,gripghs,hCox-2
|
| Uniprot Accession |
Q05769,O62698,P35355,P35354,O19183
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, NF-kappa B signaling pathway, C-type lectin receptor signaling pathway, IL-17 signaling pathway, TNF signaling pathway, Serotonergic synapse, Ovarian steroidogenesis, Oxytocin signaling pathway, Regulation of lipolysis in adipocytes, Alzheimer disease, Leishmaniasis, Human cytomegalovirus infection, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Pathways in cancer, Chemical carcinogenesis - DNA adducts, Small cell lung cancer, Arachidonic acid metabolism
|
| Gene Ensembl |
ENSMUSG00000032487, ENSBTAG00000014127, ENSCAFG00845005378, ENSG00000073756, ENSMMUG00000016857, ENSECAG00000017181
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of COX2/Cyclooxygenase 2/PTGS2/COX-2 cDNA Clones/ORF Plasmid
COX2/Cyclooxygenase 2/PTGS2/COX-2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5743 | Pre-made Human PTGS2/COX2/COX-2 siRNA oligo Duplex | 5743 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29527 | Pre-made Rat Ptgs2/Cox2/COX-2 siRNA oligo Duplex | 29527 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19225 | Pre-made Mouse Ptgs2/COX2/Cox-2 siRNA oligo Duplex | 19225 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo716671 | Pre-made Cynomolgus/Rhesus macaque PTGS2/PGHS2 siRNA oligo Duplex | 716671 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100126581 | Pre-made Cat/Feline PTGS2 siRNA oligo Duplex | 100126581 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo442942 | Pre-made Dog/Canine PTGS2/COX-2 siRNA oligo Duplex | 442942 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282023 | Pre-made Bovines/Cattle PTGS2 siRNA oligo Duplex | 282023 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo791253 | Pre-made Equine/Horse PTGS2/COX-2/PGH2S siRNA oligo Duplex | 791253 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
COX2/Cyclooxygenase 2/PTGS2/COX-2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T66665-Ab | Human | Anti-Human COX2/Cyclooxygenase 2/PTGS2/COX-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T66665-Ab | Rat | Anti-Rat COX2/Cyclooxygenase 2/PTGS2/COX-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T66665-Ab | Mouse | Anti-Mouse COX2/Cyclooxygenase 2/PTGS2/COX-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T66665-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque COX2/Cyclooxygenase 2/PTGS2/COX-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T66665-Ab | Cat/Feline | Anti-Cat/Feline COX2/Cyclooxygenase 2/PTGS2/COX-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T66665-Ab | Dog/Canine | Anti-Dog/Canine COX2/Cyclooxygenase 2/PTGS2/COX-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T66665-Ab | Bovines/Cattle | Anti-Bovines/Cattle COX2/Cyclooxygenase 2/PTGS2/COX-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T66665-Ab | Equine/Horse | Anti-Equine/Horse COX2/Cyclooxygenase 2/PTGS2/COX-2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
COX2/Cyclooxygenase 2/PTGS2/COX-2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T66665-Ag | Human | Human COX2/Cyclooxygenase 2/PTGS2/COX-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T66665-Ag | Rat | Rat COX2/Cyclooxygenase 2/PTGS2/COX-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T66665-Ag | Mouse | Mouse COX2/Cyclooxygenase 2/PTGS2/COX-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T66665-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque COX2/Cyclooxygenase 2/PTGS2/COX-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T66665-Ag | Cat/Feline | Cat/Feline COX2/Cyclooxygenase 2/PTGS2/COX-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T66665-Ag | Dog/Canine | Dog/Canine COX2/Cyclooxygenase 2/PTGS2/COX-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T66665-Ag | Bovines/Cattle | Bovines/Cattle COX2/Cyclooxygenase 2/PTGS2/COX-2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T66665-Ag | Equine/Horse | Equine/Horse COX2/Cyclooxygenase 2/PTGS2/COX-2 recombinant protein | Mammalian cell | Detail |
