Explore Complement factor D/CFD gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]
| Target ID |
GM-T66383
|
| Target Name |
Complement factor D/CFD
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
1675
|
| Gene ID |
101093500 (Felis catus), 111774154 (Equus caballus), 11537 (Mus musculus), 1675 (Homo sapiens) 485095 (Canis lupus familiaris), 505647 (Bos taurus), 54249 (Rattus norvegicus), 721138 (Macaca mulatta)
|
| Target Alternative Names |
ADIPSIN,ADN,Adipsin,Adn,C3 convertase activator,CFD,Cfd,Complement factor D,DF,Df,EVE,PFD,Properdin factor D
|
| Uniprot Accession |
P03953,P00746,Q3T0A3,P32038
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, INN Index, Cytokine Target
|
| Disease |
Dent disease
|
| Disease from KEGG |
Complement and coagulation cascades, Staphylococcus aureus infection
|
| Gene Ensembl |
ENSECAG00000036123, ENSMUSG00000061780, ENSG00000197766, ENSCAFG00845014517, ENSBTAG00000048122, ENSMMUG00000028947
|
Pre-made viral vector of Complement factor D/CFD cDNA Clones/ORF Plasmid
Complement factor D/CFD siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1675 | Pre-made Human CFD/DF/ADN siRNA oligo Duplex | 1675 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo54249 | Pre-made Rat Cfd/Df/Adn siRNA oligo Duplex | 54249 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11537 | Pre-made Mouse Cfd/DF/Adn siRNA oligo Duplex | 11537 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo721138 | Pre-made Cynomolgus/Rhesus macaque CFD siRNA oligo Duplex | 721138 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093500 | Pre-made Cat/Feline CFD siRNA oligo Duplex | 101093500 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485095 | Pre-made Dog/Canine CFD siRNA oligo Duplex | 485095 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo505647 | Pre-made Bovines/Cattle CFD/DF siRNA oligo Duplex | 505647 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo111774154 | Pre-made Equine/Horse CFD siRNA oligo Duplex | 111774154 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Complement factor D/CFD antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T66383-Ab | Human | Anti-Human Complement factor D/CFD monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T66383-Ab | Rat | Anti-Rat Complement factor D/CFD monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T66383-Ab | Mouse | Anti-Mouse Complement factor D/CFD monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T66383-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Complement factor D/CFD monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T66383-Ab | Cat/Feline | Anti-Cat/Feline Complement factor D/CFD monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T66383-Ab | Dog/Canine | Anti-Dog/Canine Complement factor D/CFD monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T66383-Ab | Bovines/Cattle | Anti-Bovines/Cattle Complement factor D/CFD monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T66383-Ab | Equine/Horse | Anti-Equine/Horse Complement factor D/CFD monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
Complement factor D/CFD recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T66383-Ag | Human | Human Complement factor D/CFD recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T66383-Ag | Rat | Rat Complement factor D/CFD recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T66383-Ag | Mouse | Mouse Complement factor D/CFD recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T66383-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Complement factor D/CFD recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T66383-Ag | Cat/Feline | Cat/Feline Complement factor D/CFD recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T66383-Ag | Dog/Canine | Dog/Canine Complement factor D/CFD recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T66383-Ag | Bovines/Cattle | Bovines/Cattle Complement factor D/CFD recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T66383-Ag | Equine/Horse | Equine/Horse Complement factor D/CFD recombinant protein | Mammalian cell | Detail |