Explore STAT1 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. [provided by RefSeq, Jun 2020]
| Target ID |
GM-T64205
|
| Target Name |
STAT1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
6772
|
| Gene ID |
100069633 (Equus caballus), 101084561 (Felis catus), 20846 (Mus musculus), 25124 (Rattus norvegicus) 488449 (Canis lupus familiaris), 510814 (Bos taurus), 6772 (Homo sapiens), 693650 (Macaca mulatta)
|
| Target Alternative Names |
2010005J02Rik,CANDF7,DD6G4-4,IMD31A,IMD31B,IMD31C,ISGF-3,STAT1,STAT91,Signal transducer and activator of transcription 1-alpha/beta,Stat1,Transcription factor ISGF-3 components p91/p84
|
| Uniprot Accession |
P42225,P42224
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer, Prostate Cancer
|
| Disease from KEGG |
Chemokine signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, NOD-like receptor signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, Prolactin signaling pathway, Thyroid hormone signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Growth hormone synthesis, secretion and action, Leishmaniasis, Toxoplasmosis, Tuberculosis, Hepatitis C, Hepatitis B, Measles, Influenza A, Human papillomavirus infection, Kaposi sarcoma-associated herpesvirus infection, Epstein-Barr virus infection, Pathways in cancer, Pancreatic cancer, PD-L1 expression and PD-1 checkpoint pathway in cancer, Inflammatory bowel disease
|
| Gene Ensembl |
ENSECAG00000009039, ENSMUSG00000026104, ENSCAFG00845025854, ENSBTAG00000007867, ENSG00000115415, ENSMMUG00000005613
|
| Target Classification |
Checkpoint-Immuno Oncology
|
Pre-made viral vector of STAT1 cDNA Clones/ORF Plasmid
STAT1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo6772 | Pre-made Human STAT1/CANDF7/IMD31A siRNA oligo Duplex | 6772 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25124 | Pre-made Rat Stat1/DD6G4-4 siRNA oligo Duplex | 25124 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo20846 | Pre-made Mouse Stat1/2010005J02Rik siRNA oligo Duplex | 20846 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo693650 | Pre-made Cynomolgus/Rhesus macaque STAT1 siRNA oligo Duplex | 693650 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101084561 | Pre-made Cat/Feline STAT1 siRNA oligo Duplex | 101084561 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo488449 | Pre-made Dog/Canine STAT1 siRNA oligo Duplex | 488449 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo510814 | Pre-made Bovines/Cattle STAT1 siRNA oligo Duplex | 510814 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100069633 | Pre-made Equine/Horse STAT1 siRNA oligo Duplex | 100069633 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
STAT1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T64205-Ab | Human | Anti-Human STAT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T64205-Ab | Rat | Anti-Rat STAT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T64205-Ab | Mouse | Anti-Mouse STAT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T64205-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque STAT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T64205-Ab | Cat/Feline | Anti-Cat/Feline STAT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T64205-Ab | Dog/Canine | Anti-Dog/Canine STAT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T64205-Ab | Bovines/Cattle | Anti-Bovines/Cattle STAT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T64205-Ab | Equine/Horse | Anti-Equine/Horse STAT1 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
STAT1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T64205-Ag | Human | Human STAT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T64205-Ag | Rat | Rat STAT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T64205-Ag | Mouse | Mouse STAT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T64205-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque STAT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T64205-Ag | Cat/Feline | Cat/Feline STAT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T64205-Ag | Dog/Canine | Dog/Canine STAT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T64205-Ag | Bovines/Cattle | Bovines/Cattle STAT1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T64205-Ag | Equine/Horse | Equine/Horse STAT1 recombinant protein | Mammalian cell | Detail |