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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
| Target ID |
GM-T63083
|
| Target Name |
RAD51
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5888
|
| Gene ID |
100071340 (Equus caballus), 101089015 (Felis catus), 19361 (Mus musculus), 403568 (Canis lupus familiaris) 499870 (Rattus norvegicus), 514749 (Bos taurus), 5888 (Homo sapiens), 708579 (Macaca mulatta)
|
| Target Alternative Names |
BRCC5,CRAD51,DNA repair protein RAD51 homolog 1,FANCR,HRAD51,HsRAD51,HsRad51,HsT16930,MRMV2,RAD51,RAD51 homolog A,RAD51A,RECA,RGD1563603,Rad51,Rad51a,Reca,hRAD51
|
| Uniprot Accession |
Q08297,Q8MKI8,Q2KJ94,Q06609
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Pathways in cancer, Pancreatic cancer
|
| Gene Ensembl |
ENSECAG00000017647, ENSMUSG00000027323, ENSCAFG00845028730, ENSBTAG00000002918, ENSG00000051180, ENSMMUG00000004579
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of RAD51 cDNA Clones/ORF Plasmid
RAD51 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5888 | Pre-made Human RAD51/RECA/BRCC5 siRNA oligo Duplex | 5888 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo499870 | Pre-made Rat Rad51/RGD1563603 siRNA oligo Duplex | 499870 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19361 | Pre-made Mouse Rad51/Reca/Rad51a siRNA oligo Duplex | 19361 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708579 | Pre-made Cynomolgus/Rhesus macaque RAD51 siRNA oligo Duplex | 708579 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101089015 | Pre-made Cat/Feline RAD51 siRNA oligo Duplex | 101089015 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403568 | Pre-made Dog/Canine RAD51/CRAD51 siRNA oligo Duplex | 403568 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo514749 | Pre-made Bovines/Cattle RAD51 siRNA oligo Duplex | 514749 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071340 | Pre-made Equine/Horse RAD51 siRNA oligo Duplex | 100071340 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
RAD51 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T63083-Ab | Human | Anti-Human RAD51 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T63083-Ab | Rat | Anti-Rat RAD51 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T63083-Ab | Mouse | Anti-Mouse RAD51 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T63083-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque RAD51 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T63083-Ab | Cat/Feline | Anti-Cat/Feline RAD51 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T63083-Ab | Dog/Canine | Anti-Dog/Canine RAD51 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T63083-Ab | Bovines/Cattle | Anti-Bovines/Cattle RAD51 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T63083-Ab | Equine/Horse | Anti-Equine/Horse RAD51 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
RAD51 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T63083-Ag | Human | Human RAD51 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T63083-Ag | Rat | Rat RAD51 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T63083-Ag | Mouse | Mouse RAD51 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T63083-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque RAD51 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T63083-Ag | Cat/Feline | Cat/Feline RAD51 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T63083-Ag | Dog/Canine | Dog/Canine RAD51 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T63083-Ag | Bovines/Cattle | Bovines/Cattle RAD51 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T63083-Ag | Equine/Horse | Equine/Horse RAD51 recombinant protein | Mammalian cell | Detail |