Explore ADRBK1/GRK2 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the G protein-coupled receptor kinase family of proteins. The encoded protein phosphorylates the beta-adrenergic receptor as well as a wide range of other substrates including non-GPCR cell surface receptors, and cytoskeletal, mitochondrial, and transcription factor proteins. Data from rodent models supports a role for this gene in embryonic development, heart function and metabolism. Elevated expression of this gene has been observed in human patients with heart failure and Alzheimer's disease. [provided by RefSeq, Sep 2017]
| Target ID |
GM-T62548
|
| Target Name |
ADRBK1/GRK2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
156
|
| Gene ID |
100059001 (Equus caballus), 101101082 (Felis catus), 110355 (Mus musculus), 156 (Homo sapiens)
25238 (Rattus norvegicus), 282682 (Bos taurus), 483701 (Canis lupus familiaris), 721754 (Macaca mulatta)
|
| Target Alternative Names |
ADRBK1,Adrbk-1,Adrbk1,BARK1,BETA-ARK1,Bark-1,Beta-ARK-1,Beta-adrenergic receptor kinase 1,G-protein coupled receptor kinase 2,GRK-2,GRK2,Grk2,beta ARK,betaARK1
|
| Uniprot Accession |
Q99MK8,P25098,P26817,P21146
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Chemokine signaling pathway, Glutamatergic synapse, Olfactory transduction, Morphine addiction
|
| Gene Ensembl |
ENSECAG00000002944, ENSMUSG00000024858, ENSG00000173020, ENSBTAG00000005832, ENSCAFG00845011204, ENSMMUG00000015925
|
Pre-made viral vector of ADRBK1/GRK2 cDNA Clones/ORF Plasmid
ADRBK1/GRK2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo156 | Pre-made Human GRK2/BARK1/ADRBK1 siRNA oligo Duplex | 156 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25238 | Pre-made Rat Grk2/BARK1/GRK-2 siRNA oligo Duplex | 25238 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo110355 | Pre-made Mouse Grk2/Adrbk1/Bark-1 siRNA oligo Duplex | 110355 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo721754 | Pre-made Cynomolgus/Rhesus macaque GRK2 siRNA oligo Duplex | 721754 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101101082 | Pre-made Cat/Feline GRK2 siRNA oligo Duplex | 101101082 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo483701 | Pre-made Dog/Canine GRK2 siRNA oligo Duplex | 483701 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282682 | Pre-made Bovines/Cattle GRK2/ADRBK1 siRNA oligo Duplex | 282682 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100059001 | Pre-made Equine/Horse GRK2 siRNA oligo Duplex | 100059001 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
ADRBK1/GRK2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T62548-Ab | Human | Anti-Human ADRBK1/GRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T62548-Ab | Rat | Anti-Rat ADRBK1/GRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T62548-Ab | Mouse | Anti-Mouse ADRBK1/GRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T62548-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque ADRBK1/GRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T62548-Ab | Cat/Feline | Anti-Cat/Feline ADRBK1/GRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T62548-Ab | Dog/Canine | Anti-Dog/Canine ADRBK1/GRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T62548-Ab | Bovines/Cattle | Anti-Bovines/Cattle ADRBK1/GRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T62548-Ab | Equine/Horse | Anti-Equine/Horse ADRBK1/GRK2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
ADRBK1/GRK2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T62548-Ag | Human | Human ADRBK1/GRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T62548-Ag | Rat | Rat ADRBK1/GRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T62548-Ag | Mouse | Mouse ADRBK1/GRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T62548-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque ADRBK1/GRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T62548-Ag | Cat/Feline | Cat/Feline ADRBK1/GRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T62548-Ag | Dog/Canine | Dog/Canine ADRBK1/GRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T62548-Ag | Bovines/Cattle | Bovines/Cattle ADRBK1/GRK2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T62548-Ag | Equine/Horse | Equine/Horse ADRBK1/GRK2 recombinant protein | Mammalian cell | Detail |
