Explore IL-2/IL2 gene products and cross-species
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]
| Target ID |
GM-T61698
|
| Target Name |
IL-2/IL2
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
3558
|
| Gene ID |
100034204 (Equus caballus), 116562 (Rattus norvegicus), 16183 (Mus musculus), 280822 (Bos taurus) 3558 (Homo sapiens), 403989 (Canis lupus familiaris), 708017 (Macaca mulatta), 751114 (Felis catus)
|
| Target Alternative Names |
IL-2,IL2,Il-2,Il2,Interleukin-2,T-cell growth factor (TCGF),TCGF,lymphokine
|
| Uniprot Accession |
P37997,P17108,P04351,P05016,P60568,Q29416,P68291,Q07885
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer, Chronic Kidney Disease
|
| Disease from KEGG |
Cytokine-cytokine receptor interaction, Viral protein interaction with cytokine and cytokine receptor, PI3K-Akt signaling pathway, C-type lectin receptor signaling pathway, JAK-STAT signaling pathway, Th1 and Th2 cell differentiation, Th17 cell differentiation, T cell receptor signaling pathway, Intestinal immune network for IgA production, Type I diabetes mellitus, Yersinia infection, Chagas disease, Measles, Human T-cell leukemia virus 1 infection, Pathways in cancer, Autoimmune thyroid disease, Inflammatory bowel disease, Allograft rejection, Graft-versus-host disease
|
| Gene Ensembl |
ENSECAG00000015616, ENSMUSG00000027720, ENSBTAG00000020883, ENSG00000109471, ENSCAFG00845020168, ENSMMUG00000021093
|
| Target Classification |
Cytokine Receptor, Checkpoint-Immuno Oncology
|
Pre-made viral vector of IL-2/IL2 cDNA Clones/ORF Plasmid
IL-2/IL2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo3558 | Pre-made Human IL2/IL-2/TCGF siRNA oligo Duplex | 3558 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo116562 | Pre-made Rat Il2 siRNA oligo Duplex | 116562 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo16183 | Pre-made Mouse Il2/Il-2 siRNA oligo Duplex | 16183 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo708017 | Pre-made Cynomolgus/Rhesus macaque IL2/IL-2 siRNA oligo Duplex | 708017 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo751114 | Pre-made Cat/Feline IL2 siRNA oligo Duplex | 751114 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403989 | Pre-made Dog/Canine IL2 siRNA oligo Duplex | 403989 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo280822 | Pre-made Bovines/Cattle IL2/IL-2/TCGF siRNA oligo Duplex | 280822 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034204 | Pre-made Equine/Horse IL2/IL-2/TCGF siRNA oligo Duplex | 100034204 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
IL-2/IL2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T61698-Ab | Human | Anti-Human IL-2/IL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T61698-Ab | Rat | Anti-Rat IL-2/IL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T61698-Ab | Mouse | Anti-Mouse IL-2/IL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T61698-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque IL-2/IL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T61698-Ab | Cat/Feline | Anti-Cat/Feline IL-2/IL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T61698-Ab | Dog/Canine | Anti-Dog/Canine IL-2/IL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T61698-Ab | Bovines/Cattle | Anti-Bovines/Cattle IL-2/IL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T61698-Ab | Equine/Horse | Anti-Equine/Horse IL-2/IL2 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
IL-2/IL2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T61698-Ag | Human | Human IL-2/IL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T61698-Ag | Rat | Rat IL-2/IL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T61698-Ag | Mouse | Mouse IL-2/IL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T61698-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque IL-2/IL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T61698-Ag | Cat/Feline | Cat/Feline IL-2/IL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T61698-Ag | Dog/Canine | Dog/Canine IL-2/IL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T61698-Ag | Bovines/Cattle | Bovines/Cattle IL-2/IL2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T61698-Ag | Equine/Horse | Equine/Horse IL-2/IL2 recombinant protein | Mammalian cell | Detail |