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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
| Target ID |
GM-T60857
|
| Target Name |
AKR1C3
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
8644
|
| Gene ID |
8644 (Homo sapiens)
|
| Target Alternative Names |
17-beta-hydroxysteroid dehydrogenase type 5 (17-beta-HSD 5),3-alpha-HSD type II,3-alpha-hydroxysteroid dehydrogenase type 2 (3-alpha-HSD type 2),AKR1C3,Aldo-keto reductase family 1 member C3,Chlordecone reductase homolog HAKRb,DD3,DD3),DDX,Dihydrodiol dehydrogenase 3 (DD-3,Dihydrodiol dehydrogenase type I,HA1753,HAKRB,HAKRe,HSD17B5,PGFS,Prostaglandin F synthase (PGFS),Testosterone 17-beta-dehydrogenase 5,brain,hluPGFS
|
| Uniprot Accession |
P42330
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Steroid hormone biosynthesis, Ovarian steroidogenesis, Arachidonic acid metabolism
|
| Gene Ensembl |
ENSG00000196139
|
| Target Classification |
Tumor-associated antigen (TAA)
|
Pre-made viral vector of AKR1C3 cDNA Clones/ORF Plasmid
AKR1C3 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo8644 | Pre-made Human AKR1C3/DD3/DDX siRNA oligo Duplex | 8644 | Human | In-vitro grade; in-vivo grade | Detail |
AKR1C3 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T60857-Ab | Human | Anti-Human AKR1C3 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
AKR1C3 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T60857-Ag | Human | Human AKR1C3 recombinant protein | Mammalian cell | Detail |
