Explore OGDH gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Introcelluar Protein.
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
| Target ID |
GM-T60636
|
| Target Name |
OGDH
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
4967
|
| Gene ID |
100065225 (Equus caballus), 101096048 (Felis catus), 18293 (Mus musculus), 360975 (Rattus norvegicus)
475499 (Canis lupus familiaris), 4967 (Homo sapiens), 698854 (Macaca mulatta)
|
| Target Alternative Names |
2-oxoglutarate dehydrogenase,2-oxoglutarate dehydrogenase complex component E1,2210403E04Rik,2210412K19Rik,AKGDH,Alpha-ketoglutarate dehydrogenase (Alpha-KGDH-E1),E1k,E1o,HsOGDH,KGD1,OGDC,OGDC-E1,OGDH,OGDH-E1,OGDH2,OGDHD,Ogdh,Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase,d1401,mKIAA4192,mitochondrial
|
| Uniprot Accession |
Q60597,Q5XI78,Q02218
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease from KEGG |
Metabolic pathways
|
| Gene Ensembl |
ENSECAG00000023953, ENSMUSG00000020456, ENSCAFG00845012087, ENSG00000105953, ENSMMUG00000002651
|
Pre-made viral vector of OGDH cDNA Clones/ORF Plasmid
OGDH siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo4967 | Pre-made Human OGDH/E1k/E1o siRNA oligo Duplex | 4967 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo360975 | Pre-made Rat Ogdh/E1o/OGDH-E1 siRNA oligo Duplex | 360975 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18293 | Pre-made Mouse Ogdh/E1o/d1401 siRNA oligo Duplex | 18293 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698854 | Pre-made Cynomolgus/Rhesus macaque OGDH siRNA oligo Duplex | 698854 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101096048 | Pre-made Cat/Feline OGDH siRNA oligo Duplex | 101096048 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo475499 | Pre-made Dog/Canine OGDH siRNA oligo Duplex | 475499 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100065225 | Pre-made Equine/Horse OGDH siRNA oligo Duplex | 100065225 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
OGDH antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T60636-Ab | Human | Anti-Human OGDH monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T60636-Ab | Rat | Anti-Rat OGDH monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T60636-Ab | Mouse | Anti-Mouse OGDH monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T60636-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque OGDH monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T60636-Ab | Cat/Feline | Anti-Cat/Feline OGDH monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T60636-Ab | Dog/Canine | Anti-Dog/Canine OGDH monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T60636-Ab | Equine/Horse | Anti-Equine/Horse OGDH monoclonal antibody | mab | Therapeutics Target antibody | Detail |
OGDH recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T60636-Ag | Human | Human OGDH recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T60636-Ag | Rat | Rat OGDH recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T60636-Ag | Mouse | Mouse OGDH recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T60636-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque OGDH recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T60636-Ag | Cat/Feline | Cat/Feline OGDH recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T60636-Ag | Dog/Canine | Dog/Canine OGDH recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T60636-Ag | Equine/Horse | Equine/Horse OGDH recombinant protein | Mammalian cell | Detail |
