Explore COX-1/Cyclooxygenase-1/PTGS1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This is one of two genes encoding similar enzymes that catalyze the conversion of arachidonate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2021]
| Target ID |
GM-T60529
|
| Target Name |
COX-1/Cyclooxygenase-1/PTGS1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5742
|
| Gene ID |
100034087 (Equus caballus), 101092557 (Felis catus), 19224 (Mus musculus), 24693 (Rattus norvegicus)
282022 (Bos taurus), 403544 (Canis lupus familiaris), 5742 (Homo sapiens), 698213 (Macaca mulatta)
|
| Target Alternative Names |
COX-1,COX-3,COX1,COX3,Cox-1,Cox-3,Cox1,Cox3,Cyclooxygenase-1,Cyclooxygenase-1 (COX-1),PCOX1,PES-1,PGG/HS,PGHS-1,PGHS1,PHS 1,PHS 1),PHS1,PTGHS,PTGS1,Pghs-1,Pghs1,Prostaglandin G/H synthase 1,Prostaglandin H2 synthase 1 (PGH synthase 1,Prostaglandin-endoperoxide synthase 1,Ptgs1
|
| Uniprot Accession |
P22437,Q63921,O62664,Q8HZR1,P23219
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target, Immuno-oncology Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Platelet activation, Serotonergic synapse, Regulation of lipolysis in adipocytes, Arachidonic acid metabolism
|
| Gene Ensembl |
ENSECAG00000009707, ENSMUSG00000047250, ENSBTAG00000006716, ENSCAFG00845013501, ENSG00000095303, ENSMMUG00000012886
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
COX-1/Cyclooxygenase-1/PTGS1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5742 | Pre-made Human PTGS1/COX1/COX3 siRNA oligo Duplex | 5742 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo24693 | Pre-made Rat Ptgs1/Cox1/Cox3 siRNA oligo Duplex | 24693 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo19224 | Pre-made Mouse Ptgs1/COX1/Cox-1 siRNA oligo Duplex | 19224 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo698213 | Pre-made Cynomolgus/Rhesus macaque PTGS1 siRNA oligo Duplex | 698213 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101092557 | Pre-made Cat/Feline PTGS1 siRNA oligo Duplex | 101092557 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo403544 | Pre-made Dog/Canine PTGS1/COX1/COX-1 siRNA oligo Duplex | 403544 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282022 | Pre-made Bovines/Cattle PTGS1 siRNA oligo Duplex | 282022 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100034087 | Pre-made Equine/Horse PTGS1/COX-1 siRNA oligo Duplex | 100034087 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
COX-1/Cyclooxygenase-1/PTGS1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T60529-Ab | Human | Anti-Human COX-1/Cyclooxygenase-1/PTGS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T60529-Ab | Rat | Anti-Rat COX-1/Cyclooxygenase-1/PTGS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T60529-Ab | Mouse | Anti-Mouse COX-1/Cyclooxygenase-1/PTGS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T60529-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque COX-1/Cyclooxygenase-1/PTGS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T60529-Ab | Cat/Feline | Anti-Cat/Feline COX-1/Cyclooxygenase-1/PTGS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T60529-Ab | Dog/Canine | Anti-Dog/Canine COX-1/Cyclooxygenase-1/PTGS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T60529-Ab | Bovines/Cattle | Anti-Bovines/Cattle COX-1/Cyclooxygenase-1/PTGS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T60529-Ab | Equine/Horse | Anti-Equine/Horse COX-1/Cyclooxygenase-1/PTGS1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
COX-1/Cyclooxygenase-1/PTGS1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T60529-Ag | Human | Human COX-1/Cyclooxygenase-1/PTGS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T60529-Ag | Rat | Rat COX-1/Cyclooxygenase-1/PTGS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T60529-Ag | Mouse | Mouse COX-1/Cyclooxygenase-1/PTGS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T60529-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque COX-1/Cyclooxygenase-1/PTGS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T60529-Ag | Cat/Feline | Cat/Feline COX-1/Cyclooxygenase-1/PTGS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T60529-Ag | Dog/Canine | Dog/Canine COX-1/Cyclooxygenase-1/PTGS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T60529-Ag | Bovines/Cattle | Bovines/Cattle COX-1/Cyclooxygenase-1/PTGS1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T60529-Ag | Equine/Horse | Equine/Horse COX-1/Cyclooxygenase-1/PTGS1 recombinant protein | Mammalian cell | Detail |
