Explore FHIT gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
| Target ID |
GM-T59720
|
| Target Name |
FHIT
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
2272
|
| Gene ID |
100057165 (Equus caballus), 100215999 (Canis lupus familiaris), 101082731 (Felis catus), 14198 (Mus musculus)
2272 (Homo sapiens), 60398 (Rattus norvegicus), 692183 (Bos taurus), 700974 (Macaca mulatta)
|
| Target Alternative Names |
5'''-P1,AP3A hydrolase (AP3Aase),AP3Aase,Adenosine 5'-monophosphoramidase FHIT,Adenylylsulfatase,Adenylylsulfate-ammonia adenylyltransferase,Bis(5'-adenosyl)-triphosphatase,Diadenosine 5',Dinucleosidetriphosphatase,FHIT,FRA3B,Fhit,Fra14A2,Fragile histidine triad protein,P3-triphosphate hydrolase
|
| Uniprot Accession |
O89106,P49789,Q9JIX3,Q1KZG4
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Lung Cancer
|
| Disease from KEGG |
Metabolic pathways, Small cell lung cancer, Non-small cell lung cancer
|
| Gene Ensembl |
ENSECAG00000049939, ENSCAFG00845017871, ENSMUSG00000060579, ENSG00000189283, ENSBTAG00000014418, ENSMMUG00000012832
|
Pre-made viral vector of FHIT cDNA Clones/ORF Plasmid
FHIT siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo2272 | Pre-made Human FHIT/FRA3B/AP3Aase siRNA oligo Duplex | 2272 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo60398 | Pre-made Rat Fhit siRNA oligo Duplex | 60398 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo14198 | Pre-made Mouse Fhit/Fra14A2 siRNA oligo Duplex | 14198 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo700974 | Pre-made Cynomolgus/Rhesus macaque FHIT siRNA oligo Duplex | 700974 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101082731 | Pre-made Cat/Feline FHIT siRNA oligo Duplex | 101082731 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100215999 | Pre-made Dog/Canine FHIT siRNA oligo Duplex | 100215999 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo692183 | Pre-made Bovines/Cattle FHIT siRNA oligo Duplex | 692183 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100057165 | Pre-made Equine/Horse FHIT siRNA oligo Duplex | 100057165 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
FHIT antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T59720-Ab | Human | Anti-Human FHIT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T59720-Ab | Rat | Anti-Rat FHIT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T59720-Ab | Mouse | Anti-Mouse FHIT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T59720-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque FHIT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T59720-Ab | Cat/Feline | Anti-Cat/Feline FHIT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T59720-Ab | Dog/Canine | Anti-Dog/Canine FHIT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T59720-Ab | Bovines/Cattle | Anti-Bovines/Cattle FHIT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T59720-Ab | Equine/Horse | Anti-Equine/Horse FHIT monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
FHIT VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T59720-Ag | Human | Human FHIT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T59720-Ag | Rat | Rat FHIT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T59720-Ag | Mouse | Mouse FHIT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T59720-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque FHIT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T59720-Ag | Cat/Feline | Cat/Feline FHIT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T59720-Ag | Dog/Canine | Dog/Canine FHIT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T59720-Ag | Bovines/Cattle | Bovines/Cattle FHIT VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T59720-Ag | Equine/Horse | Equine/Horse FHIT VLP (virus-like particle) | HEK293 | Products Developing |
