Explore CYP11B2 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Introcelluar Protein.
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T59056
|
| Target Name |
CYP11B2
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1585
|
| Gene ID |
13072 (Mus musculus), 1585 (Homo sapiens), 695914 (Macaca mulatta)
|
| Target Alternative Names |
ALDOS,Aldosterone synthase (ALDOS),Aldosterone-synthesizing enzyme,CPN2,CYP11B,CYP11B2,CYP11BL,CYPXIB2,Corticosterone 18-monooxygenase,Cpn2,Cyp11b,Cyp11b-2,Cyp11b2,Cytochrome P-450Aldo,Cytochrome P-450C18,Cytochrome P450 11B2,P-450C18,P450C18,P450aldo,Steroid 11-beta-hydroxylase,Steroid 18-hydroxylase,mitochondrial
|
| Uniprot Accession |
P15539,P19099
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer
|
| Disease from KEGG |
Metabolic pathways, Steroid hormone biosynthesis, Aldosterone synthesis and secretion
|
| Gene Ensembl |
ENSMUSG00000022589, ENSG00000179142, ENSMMUG00000000959
|
| Target Classification |
Tumor-associated antigen (TAA)
|
CYP11B2 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1585 | Pre-made Human CYP11B2/CPN2/ALDOS siRNA oligo Duplex | 1585 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13072 | Pre-made Mouse Cyp11b2/Cpn2/ALDOS siRNA oligo Duplex | 13072 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo695914 | Pre-made Cynomolgus/Rhesus macaque CYP11B2 siRNA oligo Duplex | 695914 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
CYP11B2 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T59056-Ab | Human | Anti-Human CYP11B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T59056-Ab | Mouse | Anti-Mouse CYP11B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T59056-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque CYP11B2 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
CYP11B2 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T59056-Ag | Human | Human CYP11B2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T59056-Ag | Mouse | Mouse CYP11B2 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T59056-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque CYP11B2 recombinant protein | Mammalian cell | Detail |
