Explore DKK1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Transmembrane Protein.
This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
| Target ID |
GM-T56697
|
| Target Name |
DKK1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
22943
|
| Gene ID |
100071881 (Equus caballus), 101097173 (Felis catus), 13380 (Mus musculus), 22943 (Homo sapiens)
293897 (Rattus norvegicus), 504445 (Bos taurus), 609600 (Canis lupus familiaris), 702997 (Macaca mulatta)
|
| Target Alternative Names |
DKK-1,DKK1,Dickkopf-1,Dickkopf-related protein 1,Dkk-1,Dkk1,SK,hDkk-1,mdkk-1
|
| Uniprot Accession |
O54908,O94907
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, Immuno-oncology Target, INN Index
|
| Disease |
cancer
|
| Disease from KEGG |
Wnt signaling pathway, Alzheimer disease
|
| Gene Ensembl |
ENSECAG00000017837, ENSMUSG00000024868, ENSG00000107984, ENSBTAG00000014218, ENSMMUG00000010847
|
| Target Classification |
Checkpoint-Immuno Oncology, Tumor-associated antigen (TAA)
|
Pre-made viral vector of DKK1 cDNA Clones/ORF Plasmid
DKK1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo22943 | Pre-made Human DKK1/SK/DKK-1 siRNA oligo Duplex | 22943 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo293897 | Pre-made Rat Dkk1 siRNA oligo Duplex | 293897 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo13380 | Pre-made Mouse Dkk1/mdkk-1 siRNA oligo Duplex | 13380 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo702997 | Pre-made Cynomolgus/Rhesus macaque DKK1 siRNA oligo Duplex | 702997 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101097173 | Pre-made Cat/Feline DKK1 siRNA oligo Duplex | 101097173 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo609600 | Pre-made Dog/Canine DKK1 siRNA oligo Duplex | 609600 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo504445 | Pre-made Bovines/Cattle DKK1 siRNA oligo Duplex | 504445 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100071881 | Pre-made Equine/Horse DKK1 siRNA oligo Duplex | 100071881 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
DKK1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T56697-Ab | Human | Anti-Human DKK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T56697-Ab | Rat | Anti-Rat DKK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T56697-Ab | Mouse | Anti-Mouse DKK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T56697-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque DKK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T56697-Ab | Cat/Feline | Anti-Cat/Feline DKK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T56697-Ab | Dog/Canine | Anti-Dog/Canine DKK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T56697-Ab | Bovines/Cattle | Anti-Bovines/Cattle DKK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T56697-Ab | Equine/Horse | Anti-Equine/Horse DKK1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
DKK1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T56697-Ag | Human | Human DKK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T56697-Ag | Rat | Rat DKK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T56697-Ag | Mouse | Mouse DKK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T56697-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque DKK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T56697-Ag | Cat/Feline | Cat/Feline DKK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T56697-Ag | Dog/Canine | Dog/Canine DKK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T56697-Ag | Bovines/Cattle | Bovines/Cattle DKK1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T56697-Ag | Equine/Horse | Equine/Horse DKK1 VLP (virus-like particle) | HEK293 | Products Developing |
