Explore Apolipoprotein AI/APOA1 gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The encoded preproprotein is proteolytically processed to generate the mature protein, which promotes cholesterol efflux from tissues to the liver for excretion, and is a cofactor for lecithin cholesterolacyltransferase (LCAT), an enzyme responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein. [provided by RefSeq, Dec 2015]
| Target ID |
GM-T56545
|
| Target Name |
Apolipoprotein AI/APOA1
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
335
|
| Gene ID |
100062583 (Equus caballus), 101081076 (Felis catus), 11806 (Mus musculus), 25081 (Rattus norvegicus) 281631 (Bos taurus), 335 (Homo sapiens), 479427 (Canis lupus familiaris), 696969 (Macaca mulatta)
|
| Target Alternative Names |
AMYLD3,APOA1,Alp-1,Apo-AI,ApoA-I,Apoa-1,Apoa1,Apolipoprotein A-I,Apolipoprotein A1,Apolipoprotein AI,Brp-14,HPALP2,Ltw-1,Lvtw-1,Sep-1,Sep-2,Sep2,apo(a),apo-AI,apoA-I
|
| Uniprot Accession |
Q00623,P04639,P15497,P02647,P02648,F7FQM7
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target
|
| Disease |
Ovary Cancer, Ovarian Cancer, Malignant neoplasm of bladder, Nephrotic syndrome, Nephrotic syndrome with focal and segmental glomerular lesions, Type 1 diabetes mellitus, Dent disease, Diabetic Nephropathy
|
| Disease from KEGG |
PPAR signaling pathway, Fat digestion and absorption, Vitamin digestion and absorption, Cholesterol metabolism, African trypanosomiasis, Lipid and atherosclerosis
|
| Gene Ensembl |
ENSECAG00000009752, ENSMUSG00000032083, ENSBTAG00000065859, ENSG00000118137, ENSCAFG00845004266, ENSMMUG00000044545
|
Pre-made viral vector of Apolipoprotein AI/APOA1 cDNA Clones/ORF Plasmid
Apolipoprotein AI/APOA1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo335 | Pre-made Human APOA1/AMYLD3/HPALP2 siRNA oligo Duplex | 335 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25081 | Pre-made Rat Apoa1/apoA-I siRNA oligo Duplex | 25081 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo11806 | Pre-made Mouse Apoa1/Sep2/Alp-1 siRNA oligo Duplex | 11806 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo696969 | Pre-made Cynomolgus/Rhesus macaque APOA1/Apo-AI/ApoA-I siRNA oligo Duplex | 696969 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101081076 | Pre-made Cat/Feline APOA1 siRNA oligo Duplex | 101081076 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo479427 | Pre-made Dog/Canine APOA1/Apo-AI/ApoA-I siRNA oligo Duplex | 479427 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo281631 | Pre-made Bovines/Cattle APOA1 siRNA oligo Duplex | 281631 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100062583 | Pre-made Equine/Horse APOA1 siRNA oligo Duplex | 100062583 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
Apolipoprotein AI/APOA1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T56545-Ab | Human | Anti-Human Apolipoprotein AI/APOA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T56545-Ab | Rat | Anti-Rat Apolipoprotein AI/APOA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T56545-Ab | Mouse | Anti-Mouse Apolipoprotein AI/APOA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T56545-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque Apolipoprotein AI/APOA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T56545-Ab | Cat/Feline | Anti-Cat/Feline Apolipoprotein AI/APOA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T56545-Ab | Dog/Canine | Anti-Dog/Canine Apolipoprotein AI/APOA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T56545-Ab | Bovines/Cattle | Anti-Bovines/Cattle Apolipoprotein AI/APOA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T56545-Ab | Equine/Horse | Anti-Equine/Horse Apolipoprotein AI/APOA1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
Apolipoprotein AI/APOA1 VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T56545-Ag | Human | Human Apolipoprotein AI/APOA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T56545-Ag | Rat | Rat Apolipoprotein AI/APOA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T56545-Ag | Mouse | Mouse Apolipoprotein AI/APOA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T56545-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque Apolipoprotein AI/APOA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T56545-Ag | Cat/Feline | Cat/Feline Apolipoprotein AI/APOA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T56545-Ag | Dog/Canine | Dog/Canine Apolipoprotein AI/APOA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T56545-Ag | Bovines/Cattle | Bovines/Cattle Apolipoprotein AI/APOA1 VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T56545-Ag | Equine/Horse | Equine/Horse Apolipoprotein AI/APOA1 VLP (virus-like particle) | HEK293 | Products Developing |