Explore TPP1 gene products and cross-species
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biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T56262
|
| Target Name |
TPP1
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
1200
|
| Gene ID |
100070095 (Equus caballus), 101093296 (Felis catus), 1200 (Homo sapiens), 12751 (Mus musculus)
485337 (Canis lupus familiaris), 515575 (Bos taurus), 709838 (Macaca mulatta), 83534 (Rattus norvegicus)
|
| Target Alternative Names |
TPP1,Tpp1,CLN2,GIG1,LPIC,SCAR7,TPP-1,Cln2,TPP-I
|
| Uniprot Accession |
O14773,O89023,Q9XSB8,Q0V8B6,Q9EQV6
|
| Uniprot Entry Name |
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
|
| Disease from KEGG |
Lysosome
|
| Gene Ensembl |
ENSECAG00000007829, ENSG00000166340, ENSMUSG00000030894, ENSCAFG00845008889, ENSBTAG00000015403, ENSMMUG00000007745
|
| Target Classification |
|
Pre-made viral vector of TPP1 cDNA Clones/ORF Plasmid
TPP1 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo1200 | Pre-made Human TPP1/CLN2/GIG1 siRNA oligo Duplex | 1200 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo83534 | Pre-made Rat Tpp1/Cln2 siRNA oligo Duplex | 83534 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo12751 | Pre-made Mouse Tpp1/Cln2/LPIC siRNA oligo Duplex | 12751 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo709838 | Pre-made Cynomolgus/Rhesus macaque TPP1 siRNA oligo Duplex | 709838 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101093296 | Pre-made Cat/Feline TPP1 siRNA oligo Duplex | 101093296 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo485337 | Pre-made Dog/Canine TPP1/CLN2 siRNA oligo Duplex | 485337 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo515575 | Pre-made Bovines/Cattle TPP1/CLN2/TPP-1 siRNA oligo Duplex | 515575 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100070095 | Pre-made Equine/Horse TPP1 siRNA oligo Duplex | 100070095 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
TPP1 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T56262-Ab | Human | Anti-Human TPP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T56262-Ab | Rat | Anti-Rat TPP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-mg-T56262-Ab | Mouse | Anti-Mouse TPP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T56262-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque TPP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T56262-Ab | Cat/Feline | Anti-Cat/Feline TPP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T56262-Ab | Dog/Canine | Anti-Dog/Canine TPP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T56262-Ab | Bovines/Cattle | Anti-Bovines/Cattle TPP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T56262-Ab | Equine/Horse | Anti-Equine/Horse TPP1 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
TPP1 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T56262-Ag | Human | Human TPP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T56262-Ag | Rat | Rat TPP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T56262-Ag | Mouse | Mouse TPP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T56262-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque TPP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T56262-Ag | Cat/Feline | Cat/Feline TPP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T56262-Ag | Dog/Canine | Dog/Canine TPP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T56262-Ag | Bovines/Cattle | Bovines/Cattle TPP1 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T56262-Ag | Equine/Horse | Equine/Horse TPP1 recombinant protein | Mammalian cell | Detail |
