Explore KLK6 gene products and cross-species
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insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
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Target
sublocation: Secreted Protein/Potential Cytokines.
This gene encodes a member of the kallikrein subfamily of the peptidase S1 family of serine proteases. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. The encoded preproprotein is proteolytically processed to generate the mature protease. Expression of this protease is regulated by steroid hormones and may be elevated in multiple human cancers and in serum from psoriasis patients. The encoded protease may participate in the cleavage of amyloid precursor protein and alpha-synuclein, thus implicating this protease in Alzheimer's and Parkinson's disease, respectively. This gene is located in a gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]
| Target ID |
GM-T53612
|
| Target Name |
KLK6
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
5653
|
| Gene ID |
100146510 (Equus caballus), 101088379 (Felis catus), 29245 (Rattus norvegicus), 476402 (Canis lupus familiaris) 532677 (Bos taurus), 5653 (Homo sapiens), 719776 (Macaca mulatta)
|
| Target Alternative Names |
Bssp,KLK6,KLNI,Kallikrein-6,Klk6,Klk7,Klni,Neurosin,PRSS18,PRSS9,Protease M,Prss9,SP59,Serine protease 18,Serine protease 9,Zyme,hK6
|
| Uniprot Accession |
Q92876
|
| Protein Sub-location |
Secreted Protein/Potential Cytokines
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Ovary Cancer, prostate cancer
|
| Gene Ensembl |
ENSECAG00000024749, ENSCAFG00845015332, ENSBTAG00000030482, ENSG00000167755, ENSMMUG00000061396
|
Pre-made viral vector of KLK6 cDNA Clones/ORF Plasmid
KLK6 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5653 | Pre-made Human KLK6/hK6/Bssp siRNA oligo Duplex | 5653 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo29245 | Pre-made Rat Klk6/Klni/Prss9 siRNA oligo Duplex | 29245 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo719776 | Pre-made Cynomolgus/Rhesus macaque KLK6 siRNA oligo Duplex | 719776 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101088379 | Pre-made Cat/Feline KLK6 siRNA oligo Duplex | 101088379 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo476402 | Pre-made Dog/Canine KLK6 siRNA oligo Duplex | 476402 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo532677 | Pre-made Bovines/Cattle KLK6/KLNI siRNA oligo Duplex | 532677 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100146510 | Pre-made Equine/Horse KLK6 siRNA oligo Duplex | 100146510 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
KLK6 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T53612-Ab | Human | Anti-Human KLK6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-rg-T53612-Ab | Rat | Anti-Rat KLK6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T53612-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque KLK6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-felg-T53612-Ab | Cat/Feline | Anti-Cat/Feline KLK6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-cang-T53612-Ab | Dog/Canine | Anti-Dog/Canine KLK6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T53612-Ab | Bovines/Cattle | Anti-Bovines/Cattle KLK6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
| GM-Tg-equg-T53612-Ab | Equine/Horse | Anti-Equine/Horse KLK6 monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody | Detail |
KLK6 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T53612-Ag | Human | Human KLK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T53612-Ag | Rat | Rat KLK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T53612-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque KLK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T53612-Ag | Cat/Feline | Cat/Feline KLK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T53612-Ag | Dog/Canine | Dog/Canine KLK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T53612-Ag | Bovines/Cattle | Bovines/Cattle KLK6 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T53612-Ag | Equine/Horse | Equine/Horse KLK6 recombinant protein | Mammalian cell | Detail |