Explore XRCC5/Ku80 gene products and cross-species
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Target
sublocation: Introcelluar Protein.
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
| Target ID |
GM-T53562
|
| Target Name |
XRCC5/Ku80
|
Gene Group ldentifer (Target Gene ID in Homo
species)
|
7520
|
| Gene ID |
100055031 (Equus caballus), 101083534 (Felis catus), 22596 (Mus musculus), 363247 (Rattus norvegicus) 478902 (Canis lupus familiaris), 531945 (Bos taurus), 574279 (Macaca mulatta), 7520 (Homo sapiens)
|
| Target Alternative Names |
86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit (CTC85,CTC85,CTCBF,CTCBF),DNA repair protein XRCC5,KARP-1,KARP1,KU80,KUB2,Ku80,Ku86,Kup80,Lupus Ku autoantigen protein p86,NFIV,Nuclear factor IV,Thyroid-lupus autoantigen (TLAA),X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining),X-ray repair cross-complementing protein 5,XRCC5,Xrcc5
|
| Uniprot Accession |
P27641,P13010
|
| Protein Sub-location |
Introcelluar Protein
|
| Category |
Therapeutics Target
|
| Disease |
cancer, Lung Cancer
|
| Gene Ensembl |
ENSECAG00000015940, ENSMUSG00000026187, ENSCAFG00845023719, ENSBTAG00000010426, ENSMMUG00000001927, ENSG00000079246
|
Pre-made viral vector of XRCC5/Ku80 cDNA Clones/ORF Plasmid
XRCC5/Ku80 siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo7520 | Pre-made Human XRCC5/KU80/KUB2 siRNA oligo Duplex | 7520 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo363247 | Pre-made Rat Xrcc5/Ku80/Kup80 siRNA oligo Duplex | 363247 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo22596 | Pre-made Mouse Xrcc5/Ku80/Ku86 siRNA oligo Duplex | 22596 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo574279 | Pre-made Cynomolgus/Rhesus macaque XRCC5 siRNA oligo Duplex | 574279 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101083534 | Pre-made Cat/Feline XRCC5 siRNA oligo Duplex | 101083534 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo478902 | Pre-made Dog/Canine XRCC5/Ku80 siRNA oligo Duplex | 478902 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo531945 | Pre-made Bovines/Cattle XRCC5 siRNA oligo Duplex | 531945 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100055031 | Pre-made Equine/Horse XRCC5 siRNA oligo Duplex | 100055031 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
XRCC5/Ku80 antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T53562-Ab | Human | Anti-Human XRCC5/Ku80 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-rg-T53562-Ab | Rat | Anti-Rat XRCC5/Ku80 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-mg-T53562-Ab | Mouse | Anti-Mouse XRCC5/Ku80 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cynog-T53562-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque XRCC5/Ku80 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-felg-T53562-Ab | Cat/Feline | Anti-Cat/Feline XRCC5/Ku80 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-cang-T53562-Ab | Dog/Canine | Anti-Dog/Canine XRCC5/Ku80 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-bovg-T53562-Ab | Bovines/Cattle | Anti-Bovines/Cattle XRCC5/Ku80 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
| GM-Tg-equg-T53562-Ab | Equine/Horse | Anti-Equine/Horse XRCC5/Ku80 monoclonal antibody | mab | Therapeutics Target antibody | Detail |
XRCC5/Ku80 recombinant protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T53562-Ag | Human | Human XRCC5/Ku80 recombinant protein | Mammalian cell | Detail |
| GM-Tg-rg-T53562-Ag | Rat | Rat XRCC5/Ku80 recombinant protein | Mammalian cell | Detail |
| GM-Tg-mg-T53562-Ag | Mouse | Mouse XRCC5/Ku80 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cynog-T53562-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque XRCC5/Ku80 recombinant protein | Mammalian cell | Detail |
| GM-Tg-felg-T53562-Ag | Cat/Feline | Cat/Feline XRCC5/Ku80 recombinant protein | Mammalian cell | Detail |
| GM-Tg-cang-T53562-Ag | Dog/Canine | Dog/Canine XRCC5/Ku80 recombinant protein | Mammalian cell | Detail |
| GM-Tg-bovg-T53562-Ag | Bovines/Cattle | Bovines/Cattle XRCC5/Ku80 recombinant protein | Mammalian cell | Detail |
| GM-Tg-equg-T53562-Ag | Equine/Horse | Equine/Horse XRCC5/Ku80 recombinant protein | Mammalian cell | Detail |