Explore PDGFR alpha/CD140a/PDGFRA gene products and cross-species
research data at TarMart platform. Discover comprehensive
biological information, expression tools, and therapeutic
insights for Homo sapiens (human), Cynomolgus monkeys, rodents
(mouse/rat), canines, felines, bovines, and equines. Your
premier destination for multi-species gene research solutions
Target
sublocation: Transmembrane Protein.
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
| Target ID |
GM-T53524
|
| Target Name |
PDGFR alpha/CD140a/PDGFRA
|
Gene Group ldentifer
（Target Gene ID in Homo
species)
|
5156
|
| Gene ID |
100059815 (Equus caballus), 101090765 (Felis catus), 18595 (Mus musculus), 25267 (Rattus norvegicus)
282301 (Bos taurus), 442860 (Canis lupus familiaris), 5156 (Homo sapiens), 697002 (Macaca mulatta)
|
| Target Alternative Names |
APDGFR,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140A,CD140a,CD140a antigen,PDGF-R-alpha,PDGFACE,PDGFR alpha,PDGFR-2,PDGFR-alpha,PDGFR2,PDGFRA,Pdgfr-2,Pdgfra,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2 (PDGFR-2),Platelet-derived growth factor receptor alpha
|
| Uniprot Accession |
P26618,P20786,P16234
|
| Protein Sub-location |
Transmembrane Protein
|
| Category |
Therapeutics Target, INN Index, Cytokine Target
|
| Disease |
cancer, Non-Small Cell Lung Cancer
|
| Disease from KEGG |
EGFR tyrosine kinase inhibitor resistance, MAPK signaling pathway, Ras signaling pathway, Rap1 signaling pathway, Calcium signaling pathway, Phospholipase D signaling pathway, PI3K-Akt signaling pathway, Focal adhesion, Gap junction, JAK-STAT signaling pathway, Regulation of actin cytoskeleton, Human cytomegalovirus infection, Pathways in cancer, Glioma, Prostate cancer, Melanoma, Central carbon metabolism in cancer, Choline metabolism in cancer
|
| Gene Ensembl |
ENSECAG00000018176, ENSMUSG00000029231, ENSBTAG00000007173, ENSCAFG00845011775, ENSG00000134853, ENSMMUG00000017395
|
| Target Classification |
Kinase
|
Pre-made viral vector of PDGFR alpha/CD140a/PDGFRA cDNA Clones/ORF Plasmid
PDGFR alpha/CD140a/PDGFRA siRNA/miRNA/oligo for RNA interfence (RNAi)
| Cat No. | Product Name | GeneID | Species | Grade | Detail |
|---|
| pGMoligo5156 | Pre-made Human PDGFRA/CD140A/PDGFR2 siRNA oligo Duplex | 5156 | Human | In-vitro grade; in-vivo grade | Detail |
| pGMoligo25267 | Pre-made Rat Pdgfra/APDGFR/PDGFACE siRNA oligo Duplex | 25267 | Rat | In-vitro grade; in-vivo grade | Detail |
| pGMoligo18595 | Pre-made Mouse Pdgfra/CD140a/Pdgfr-2 siRNA oligo Duplex | 18595 | Mouse | In-vitro grade; in-vivo grade | Detail |
| pGMoligo697002 | Pre-made Cynomolgus/Rhesus macaque PDGFRA siRNA oligo Duplex | 697002 | Cynomolgus/Rhesus macaque | In-vitro grade; in-vivo grade | Detail |
| pGMoligo101090765 | Pre-made Cat/Feline PDGFRA siRNA oligo Duplex | 101090765 | Cat/Feline | In-vitro grade; in-vivo grade | Detail |
| pGMoligo442860 | Pre-made Dog/Canine PDGFRA siRNA oligo Duplex | 442860 | Dog/Canine | In-vitro grade; in-vivo grade | Detail |
| pGMoligo282301 | Pre-made Bovines/Cattle PDGFRA siRNA oligo Duplex | 282301 | Bovines/Cattle | In-vitro grade; in-vivo grade | Detail |
| pGMoligo100059815 | Pre-made Equine/Horse PDGFRA siRNA oligo Duplex | 100059815 | Equine/Horse | In-vitro grade; in-vivo grade | Detail |
PDGFR alpha/CD140a/PDGFRA antibody/GMab
| Cat No. | Species | Antibody Name | Format | Classified by tag | Detail |
|---|
| GM-Tg-hg-T53524-Ab | Human | Anti-Human PDGFR alpha/CD140a/PDGFRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-rg-T53524-Ab | Rat | Anti-Rat PDGFR alpha/CD140a/PDGFRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-mg-T53524-Ab | Mouse | Anti-Mouse PDGFR alpha/CD140a/PDGFRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cynog-T53524-Ab | Cynomolgus/Rhesus macaque | Anti-Cynomolgus/Rhesus macaque PDGFR alpha/CD140a/PDGFRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-felg-T53524-Ab | Cat/Feline | Anti-Cat/Feline PDGFR alpha/CD140a/PDGFRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-cang-T53524-Ab | Dog/Canine | Anti-Dog/Canine PDGFR alpha/CD140a/PDGFRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-bovg-T53524-Ab | Bovines/Cattle | Anti-Bovines/Cattle PDGFR alpha/CD140a/PDGFRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
| GM-Tg-equg-T53524-Ab | Equine/Horse | Anti-Equine/Horse PDGFR alpha/CD140a/PDGFRA monoclonal antibody | mab | FACS/Biofunctional Antibody, Therapeutics Target antibody, Cytokine antibody | Detail |
PDGFR alpha/CD140a/PDGFRA VLP (virus-like particle)/protein
| Cat No. | Species | Antigen Name | Expression Platform | Detail |
|---|
| GM-Tg-hg-T53524-Ag | Human | Human PDGFR alpha/CD140a/PDGFRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-rg-T53524-Ag | Rat | Rat PDGFR alpha/CD140a/PDGFRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-mg-T53524-Ag | Mouse | Mouse PDGFR alpha/CD140a/PDGFRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cynog-T53524-Ag | Cynomolgus/Rhesus macaque | Cynomolgus/Rhesus macaque PDGFR alpha/CD140a/PDGFRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-felg-T53524-Ag | Cat/Feline | Cat/Feline PDGFR alpha/CD140a/PDGFRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-cang-T53524-Ag | Dog/Canine | Dog/Canine PDGFR alpha/CD140a/PDGFRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-bovg-T53524-Ag | Bovines/Cattle | Bovines/Cattle PDGFR alpha/CD140a/PDGFRA VLP (virus-like particle) | HEK293 | Products Developing |
| GM-Tg-equg-T53524-Ag | Equine/Horse | Equine/Horse PDGFR alpha/CD140a/PDGFRA VLP (virus-like particle) | HEK293 | Products Developing |
